| Comparative trial of sulphasalazine and oral sodium cromoglycate in the maintenance of remission in ulcerative colitis. | |
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MedLine Citation:
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PMID: 33875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with ulcerative colitis in remission were randomly allocated to treatment with sulphasalazine (2 g/day) or oral sodium cromoglycate (160 mg/day or 2 g/day), and the relapse rates in these treatment groups were compared during continued treatment for one year. The percentage cumulative relapse rate after 12 months' treatment was 30% in the 33 patients treated with sulphasalazine compared with 71% in the 25 treated with high dose sodium cromoglycate, a highly significant difference (P less than 0.01). Patients allocated low dose sodium cromoglycate were only treated for a maximum of six months, and the relapse rate in these 12 patients was similar to that in patients on the high dose. These results suggest that oral sodium cromoglycate is considerably less effective than sulphasalazine in maintaining remission, and by analogy with results in other trials may be no more effective than placebo tablets. |
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Authors:
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M W Dronfield; M J Langman |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Gut Volume: 19 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-05-26 Completed Date: 1979-05-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1136-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clinical Trials as Topic Colitis, Ulcerative / drug therapy* Cromolyn Sodium / therapeutic use* Dose-Response Relationship, Drug Female Humans Male Remission, Spontaneous Sulfasalazine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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15826-37-6/Cromolyn Sodium; 599-79-1/Sulfasalazine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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