Document Detail

Comparative trial of norfloxacin and macrocrystalline nitrofurantoin (Macrodantin) in the prophylaxis of recurrent urinary tract infection in women.
MedLine Citation:
PMID:  1801054     Owner:  NLM     Status:  MEDLINE    
Eighty-eight women with a history of recurrent urinary tract infection (at least four attacks in the preceding 12 months) were randomized to take either norfloxacin 200 mg at night (45 patients) or macrocrystalline nitrofurantoin 100 mg at night (43 patients) for 12 months. A decrease in the number of symptomatic attacks while taking this prophylaxis was observed in 94 per cent of the patients and this improvement was maintained during the 6 months following the end of prophylaxis in 69 per cent. The mean interval between symptomatic episodes while taking prophylaxis was 7.2-fold and 6.9-fold greater, respectively, than in the 12 months before starting prophylaxis. There were only nine breakthrough infections during 74 patient-years of prophylaxis, four in patients taking norfloxacin (two enterococci, one Staphylococcus epidermidis, one Escherichia coli), and five in those taking macrocrystalline nitrofurantoin (four E. coli, one Klebsiella pneumoniae). Adverse events caused four patients taking norfloxacin (8 per cent) and seven taking macrocrystalline nitrofurantoin (14 per cent) to stop prophylaxis. Norfloxacin had a marked suppressive effect on the coliform part of the faecal flora, with no emergence of resistance. Thus, norfloxacin appears to be an excellent alternative agent to macrocrystalline nitrofurantoin for the prevention of recurrent urinary infections.
W Brumfitt; J M Hamilton-Miller; G W Smith; W al-Wali
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Quarterly journal of medicine     Volume:  81     ISSN:  0033-5622     ISO Abbreviation:  Q. J. Med.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401027     Medline TA:  Q J Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  811-20     Citation Subset:  IM    
Department of Medical Microbiology, Royal Free Hospital, London, UK.
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MeSH Terms
Aged, 80 and over
Middle Aged
Nitrofurantoin / therapeutic use*
Norfloxacin / therapeutic use*
Time Factors
Urinary Tract Infections / microbiology,  prevention & control*
Reg. No./Substance:
67-20-9/Nitrofurantoin; 70458-96-7/Norfloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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