| Comparative trial of norfloxacin and macrocrystalline nitrofurantoin (Macrodantin) in the prophylaxis of recurrent urinary tract infection in women. | |
| | |
MedLine Citation:
|
PMID: 1801054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Eighty-eight women with a history of recurrent urinary tract infection (at least four attacks in the preceding 12 months) were randomized to take either norfloxacin 200 mg at night (45 patients) or macrocrystalline nitrofurantoin 100 mg at night (43 patients) for 12 months. A decrease in the number of symptomatic attacks while taking this prophylaxis was observed in 94 per cent of the patients and this improvement was maintained during the 6 months following the end of prophylaxis in 69 per cent. The mean interval between symptomatic episodes while taking prophylaxis was 7.2-fold and 6.9-fold greater, respectively, than in the 12 months before starting prophylaxis. There were only nine breakthrough infections during 74 patient-years of prophylaxis, four in patients taking norfloxacin (two enterococci, one Staphylococcus epidermidis, one Escherichia coli), and five in those taking macrocrystalline nitrofurantoin (four E. coli, one Klebsiella pneumoniae). Adverse events caused four patients taking norfloxacin (8 per cent) and seven taking macrocrystalline nitrofurantoin (14 per cent) to stop prophylaxis. Norfloxacin had a marked suppressive effect on the coliform part of the faecal flora, with no emergence of resistance. Thus, norfloxacin appears to be an excellent alternative agent to macrocrystalline nitrofurantoin for the prevention of recurrent urinary infections. |
| | |
Authors:
|
W Brumfitt; J M Hamilton-Miller; G W Smith; W al-Wali |
Related Documents
:
|
15813644 - Psychological symptoms associated with genital herpes virus infections: epidemiology an... 19805964 - Nodular lymphoid hyperplasia in common variable immunodeficiency syndrome mimicking fam... 16412054 - Recurrent infections in partial complement factor i deficiency: evaluation of three gen... 20832054 - Recurrent skin and soft tissue infections due to methicillin-resistant staphylococcus a... 23548214 - Development of a chip-based multiplexed immunoassay using liposomal nanovesicles and it... 16120634 - Strategies for managing systemic fungal infection and the place of itraconazole. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The Quarterly journal of medicine Volume: 81 ISSN: 0033-5622 ISO Abbreviation: Q. J. Med. Publication Date: 1991 Oct |
Date Detail:
|
Created Date: 1992-04-21 Completed Date: 1992-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0401027 Medline TA: Q J Med Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 811-20 Citation Subset: IM |
Affiliation:
|
Department of Medical Microbiology, Royal Free Hospital, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Female Humans Middle Aged Nitrofurantoin / therapeutic use* Norfloxacin / therapeutic use* Recurrence Time Factors Urinary Tract Infections / microbiology, prevention & control* |
| Chemical | |
Reg. No./Substance:
|
67-20-9/Nitrofurantoin; 70458-96-7/Norfloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chance as an explanatory factor in evolutionary biology.
Next Document: Out-of-hospital ventricular fibrillation in patients under the age of 40 years and the long-term pro...