| Comparative trial of local pharmacotherapy with L-arginine, r-hirudin, and molsidomine to reduce restenosis after balloon angioplasty of stenotic rabbit iliac arteries. | |
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MedLine Citation:
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PMID: 11376260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine if local application of L-arginine, r-hirudin, or molsidomine significantly reduces restenosis after balloon angioplasty in stenotic rabbit iliac arteries. MATERIALS AND METHODS: Thirty-one male cholesterol-fed New Zealand white rabbits underwent balloon dilation of both common iliac arteries to induce arterial stenosis. Four weeks later, one stenotic iliac artery was simultaneously dilated and received local application of L-arginine (210 mg/mL, n = 7), r-hirudin (0.5 mg/mL, n = 8), or molsidomine (0.2 mg/mL, n = 8) with a channeled balloon catheter. On the contralateral side, 0.9% saline was injected as a control. In eight sham animals, saline was applied to one iliac artery and balloon dilation to only the contralateral artery. Six weeks after local treatment, vessels were harvested, and computerized morphometric and immunohistologic analyses were performed. RESULTS: Application of drugs resulted in a significant reduction of neointimal area as follows: 53% with L-arginine (1.01 mm(2) vs. 2.17 mm(2), P <.05), 43% with molsidomine (1.04 mm(2) vs. 1.89 mm(2), P <.05), and 20% with r-hirudin (1.79 mm(2) vs. 2.24 mm(2), P <.05). Infusion of saline led to a significant increase (50%, 1.21 mm(2) vs. 1.93 mm(2), P <.05) in neointimal area compared with balloon dilation alone. Immunohistologic findings showed a significant reduction of macrophages (5.0% vs. 10.2%, P <.05) and proliferating cells (6.2% vs. 10.6%, P <.05) in the neointima after local application of L-arginine. CONCLUSION: Reduction of neointimal area was significant for L-arginine and molsidomine but not for r-hirudin. Saline infusion caused significant arterial trauma, resulting in additional neointimal proliferation. |
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Authors:
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M Kalinowski; H Alfke; S Bergen; K J Klose; J J Barry; H J Wagner |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Radiology Volume: 219 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-28 Completed Date: 2001-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 716-23 Citation Subset: AIM; IM |
Affiliation:
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Department of Diagnostic Radiology, Philipps-University Hospital, Marburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Angioplasty, Balloon* Animals Antithrombins / administration & dosage, therapeutic use* Arginine / administration & dosage, therapeutic use* Constriction, Pathologic / prevention & control Hirudin Therapy* Hirudins / administration & dosage Iliac Artery* Male Molsidomine / administration & dosage, therapeutic use* Nitric Oxide Donors / administration & dosage, therapeutic use* Rabbits Recurrence Vasodilator Agents / administration & dosage, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antithrombins; 0/Hirudins; 0/Nitric Oxide Donors; 0/Vasodilator Agents; 25717-80-0/Molsidomine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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