Document Detail

Comparative transcriptome analyses reveal conserved and distinct mechanisms in ovine and bovine lactation.
MedLine Citation:
PMID:  23324993     Owner:  NLM     Status:  Publisher    
A combined analysis of a bovine and ovine mammary gland transcriptome from two similarly designed microarray experiments suggested a strong positive association between the differentially expressed genes (DEGs) implying that major pathways regulating the lactation process were evolutionarily conserved within the two species. Some distinct pathways identified indicate the physiological differences underlying the species. Novel techniques were established for the combined analysis of the transcriptomes of different species or heterogeneous platforms for comparative gene expression analysis allowing for greater experimental power to detect conserved pathways. Conserved DEGs were mainly related to lipid metabolism, amino acid synthesis, cell proliferation, signaling and immune systems indicating functional processes involved in the regulation of lactation including milk synthesis and lactation persistency. There were no functionally annotated DEGs that show antagonistic expression between sheep and cattle suggesting that the lactation process is essentially the same in the two species. DEGs that were found exclusively in sheep were mostly associated with gland morphogenesis while DEGs exclusively expressed in cattle, indicated that certain immune response and milk composition mechanisms were different in the bovine as compared to sheep. The conserved processes across the two species suggest the use of the ovine as a suitable model for lactation studies, considering the challenges and expense of conducting lactation physiology and genomics studies within the cow.
Mini Singh; Peter C Thomson; Paul A Sheehy; Herman W Raadsma
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Functional & integrative genomics     Volume:  -     ISSN:  1438-7948     ISO Abbreviation:  Funct. Integr. Genomics     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939343     Medline TA:  Funct Integr Genomics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia,
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