Document Detail

Comparative toxicity studies in birds using nimesulide and diclofenac sodium.
MedLine Citation:
PMID:  21783701     Owner:  NLM     Status:  In-Data-Review    
Nimesulide, a sulfonanilide derivative, was compared with diclofenac sodium for toxicity in poultry. In this study, Vanaraja and PB1 birds of 6 weeks old (either sex) were mixed and equally divided into 5 groups of 10 birds each. The birds were inoculated with nimesulide, @ 5 and 2mg; vehicle @ 0.5ml; and diclofenac sodium @ 5mg on kg bwt basis. One group served as untreated control. All the groups were observed for a period of 28days. Forty percent mortality was observed within 12 days in diclofenac-treated group. While birds inoculated with nimesulide remained normal. No significant differences in the weight gain, haematology, total protein contents in the nimesulide and diclofenac groups (survived birds) were observed when compared with the control group of birds. Serum creatinine, cholesterol, alkaline phosphatase, and aspartate aminotransferase levels were significantly (P<0.05) high in diclofenac-treated group compared to nimesulide (P>0.05) and control groups. Nimesulide-treated groups did not show any histopathological lesions, where as diclofenac-treated birds showed histopathological lesions in liver and kidney.
N C Prakash Reddy; Y Anjaneyulu; B Sivasankari; K Ananda Rao
Publication Detail:
Type:  Journal Article     Date:  2006-03-29
Journal Detail:
Title:  Environmental toxicology and pharmacology     Volume:  22     ISSN:  1382-6689     ISO Abbreviation:  Environ. Toxicol. Pharmacol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2011-07-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612020     Medline TA:  Environ Toxicol Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  142-7     Citation Subset:  -    
Indian Immunologicals Limited, Rakshapuram, Gachibowli, Hyderabad 500 019, India.
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