Document Detail

Comparative topical pheromonotropic activity of insect pyrokinin/PBAN amphiphilic analogs incorporating different fatty and/or cholic acid components.
MedLine Citation:
PMID:  11179822     Owner:  NLM     Status:  MEDLINE    
This study presents a comparison of the topical pheromonotropic activity in the tobacco budworm moth of a series of amphiphilic pseudopeptide analogs of the insect pyrokinin/PBAN peptide class incorporating fatty acids of varying chain lengths. While the C16 analog fails to penetrate the moth cuticle, and the C12 only moderately so, shorter chain analogs transmigrate the moth cuticle readily with decreasing cuticle-retention properties. A cholic acid analog topically induces twice the maximal pheromone titer of injected native hormone. From a pest management perspective, these non-aromatic hydrophobic components are expected to be more environmentally benign than benzenoid components previously used in topical insect peptide analogs.
R J Nachman; P E Teal; I Ujvary
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  22     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-85     Citation Subset:  IM    
Southern Plains Agricultural Research Center, USDA, ARS, College Station, TX 77845, USA.
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MeSH Terms
Cholic Acid
Fatty Acids
Moths / physiology*
Neuropeptides / chemistry*,  physiology*
Structure-Activity Relationship
Reg. No./Substance:
0/Fatty Acids; 0/Neuropeptides; 0/pyrokinin; 81-25-4/Cholic Acid

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