Document Detail

Comparative tolerance and complications in a multicentre trial of intracoronary streptokinase and intravenous anisoylated plasminogen streptokinase activator complex in acute myocardial infarction.
MedLine Citation:
PMID:  3315606     Owner:  NLM     Status:  MEDLINE    
The safety and tolerance data of the preliminary results of a randomised, parallel group, multicentre trial of intracoronary streptokinase and intravenous anisoylated plasminogen streptokinase activator complex (APSAC) in patients with myocardial infarction are presented. The frequency of side effects was similar in the 2 groups. The most frequently encountered side effect was bleeding, overwhelmingly from the groin puncture site from angiography. There was no significant difference between amount or incidence of bleeding complications between the two groups, as measured by number of bleeding episodes, transfusion requirements, or mean drop in haematocrit or haemoglobin.
R L Rothbard
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Drugs     Volume:  33 Suppl 3     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-07     Completed Date:  1988-01-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  276-8     Citation Subset:  IM    
University of Rochester, School of Medicine and Dentistry.
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MeSH Terms
Clinical Trials as Topic
Fibrinolytic Agents / adverse effects*,  therapeutic use
Hemoglobins / drug effects
Hemorrhage / chemically induced
Myocardial Infarction / drug therapy*
Plasminogen / adverse effects*,  therapeutic use
Random Allocation
Streptokinase / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Hemoglobins; 81669-57-0/Anistreplase; 9001-91-6/Plasminogen; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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