Document Detail


Comparative subchronic studies on 2,4-dichlorophenoxyacetic acid, amine, and ester in rats.
MedLine Citation:
PMID:  8921334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forms of 2,4-dichlorophenoxyacetic acid (collectively known as 2,4-D) are herbicides used to control a wide variety of broadleaf and woody plants. Subchronic toxicity studies in rats were conducted on three forms of 2,4-D: the parent form, 2,4-D acid; 2,4-D dimethylamine salt (DMA); and 2,4-D 2-ethylhexyl ester (2-EHE). Doses in the subchronic studies (on an acid equivalent basis) were 0, 1, 15, 100, and 300 mg/kg/day. Major treatment related findings in the three studies included decreases in red cell mass, decreases in T3 and T4 levels, decreases in ovary and testes weights, increases in liver, kidney, and thyroid weights, and cataracts and retinal degeneration (high-dose females). These data demonstrated the comparable toxicities of 2,4-D acid, DMA, and 2-EHE and support a subchronic no-observed-effect level of 15 mg/kg/day for all three forms. In summary, the findings of these studies indicate comparable low subchronic toxicity potentials among representative forms of 2,4-D.
Authors:
J M Charles; H C Cunny; R D Wilson; J S Bus
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fundamental and applied toxicology : official journal of the Society of Toxicology     Volume:  33     ISSN:  0272-0590     ISO Abbreviation:  Fundam Appl Toxicol     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-03-04     Completed Date:  1997-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200838     Medline TA:  Fundam Appl Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Affiliation:
Charles, Conn, & van Gemert, LLC, Durham, North Carolina 27705, USA.
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MeSH Terms
Descriptor/Qualifier:
2,4-Dichlorophenoxyacetic Acid / toxicity*
Animals
Blood Cells / drug effects
Body Weight / drug effects
Dimethylamines / toxicity*
Esters / chemistry
Feeding Behavior / drug effects
Female
Male
No-Observed-Adverse-Effect Level
Organ Size / drug effects
Rats
Rats, Inbred F344
Chemical
Reg. No./Substance:
0/Dimethylamines; 0/Esters; 2008-39-1/2,4-D amine; 94-75-7/2,4-Dichlorophenoxyacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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