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Comparative study of thyrotoxic periodic paralysis from idiopathic hypokalemic periodic paralysis: An experience from India.
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PMID:  22919190     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: There is paucity of reports on thyrotoxic periodic paralysis (TPP) from India. We report the patients with TPP and compare them with idiopathic hypokalemic periodic paralysis (IHPP).
MATERIALS AND METHODS: Patients with hypokalemic periodic paralysis (HPP) treated during the past 11 years were evaluated retrospectively. Their demographic parameters, family history, clinical features, precipitating factors, severity of weakness, laboratory parameters and rapidity of recovery were recorded. The demographic, clinical and laboratory parameters of TPP and IHPP were compared.
RESULTS: During the study period, we managed 52 patients with HPP; nine (17.3%) of whom had TPP and 27 (52%) had IHPP. The demographic, precipitating factors, number of attacks and severity of limb weakness were similar between the TPP and IHPP groups, except in the IHPP group, bulbar weakness was present in four and respiratory paralysis in six, needing artificial ventilation in two patients. Serum potassium was significantly lower in TPP (2.21 ± 0.49) compared with IHPP (2.67 ± 0.59, P = 0.04). Four patients with TPP had subclinical thyrotoxicosis and two had subclinical hyperthyroidism. Rebound hyperkalemia occurred in both TPP and IHPP (three versus eight patients). The recovery was faster in IHPP (26.7 ± 15.4 h) compared with TPP (34.0 ± 14.0 h), but was statistically insignificant.
CONCLUSION: TPP constitutes 17.3% of HPP, and absence of clinical features of thyrotoxicosis and subclinical hyperthyroidism in TPP is not uncommon. Clinical features, demographic profile and rebound hyperkalemia are similar in both TPP and IHPP. The serum potassium level is significantly low in the TPP compared with the IHPP group.
Authors:
J Kalita; G Goyal; S K Bhoi; S Chandra; U K Misra
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of Indian Academy of Neurology     Volume:  15     ISSN:  1998-3549     ISO Abbreviation:  Ann Indian Acad Neurol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-10-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101273955     Medline TA:  Ann Indian Acad Neurol     Country:  India    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  -    
Affiliation:
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
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Journal Information
Journal ID (nlm-ta): Ann Indian Acad Neurol
Journal ID (iso-abbrev): Ann Indian Acad Neurol
Journal ID (publisher-id): AIAN
ISSN: 0972-2327
ISSN: 1998-3549
Publisher: Medknow Publications & Media Pvt Ltd, India
Article Information
Copyright: © Annals of Indian Academy of Neurology
open-access:
Received Day: 17 Month: 1 Year: 2012
Revision Received Day: 12 Month: 2 Year: 2012
Accepted Day: 05 Month: 3 Year: 2012
Print publication date: Season: Jul-Sep Year: 2012
Volume: 15 Issue: 3
First Page: 186 Last Page: 190
ID: 3424795
PubMed Id: 22919190
Publisher Id: AIAN-15-186
DOI: 10.4103/0972-2327.99708

Comparative study of thyrotoxic periodic paralysis from idiopathic hypokalemic periodic paralysis: An experience from India
J. Kalitaaff1
G. Goyalaff1
S. K. Bhoiaff1
S. Chandraaff1
U. K. Misraaff1
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Correspondence: For correspondence: Dr. U. K. Misra, Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow - 226 014, India. E-mail: drukmisra@rediffmail.com

Introduction

Association of periodic paralysis and thyrotoxicosis had been documented by Rosenfeld as early as 1902.[1] Thyrotoxic periodic paralysis (TPP) is more commonly reported in Oriental Asians.[2, 3] It has also been reported from the western countries as a result of migration of different ethnic populations.[4, 5] TPP is a serious complication of hyperthyroidism, which is characterized by muscle paralysis and hypokalemia due to a massive intracellular shift of potassium. The thyrotoxic patients have an underlying tendency for muscle Na/K-ATPase overactivity, which is aggravated by insulin, catecholamines or exercise.[6] The overactivity of Na/K-ATPase drives serum potassium into the intracellular compartment causing hyperpolarization, apparent hypokalemia and muscle weakness. There are isolated case reports on TPP from India, but there is no comprehensive study about their clinical, laboratory parameters and outcome.[710] TPP should be differentiated from idiopathic hypokalemic periodic paralysis (IHPP), as these require specific treatment. We report the clinical and laboratory findings in nine patients with TPP who were managed by us in the last 11 years and compare their clinical and laboratory findings with IHPP.


Materials and Methods

The records of patients with hypokalemic periodic paralysis (HPP) managed by us during Jan 2001 to 30 June 2011 were extracted from the computerized hospital information system. The patients’ demographic and clinical data, including age, gender, family history of similar illness and thyroid disorders, drug intake, duration of illness, number of attacks, duration of each attack and precipitating factors (exercise, diet, alcohol, infections and stress), were noted. During the hospitalization, the severity of weakness, presence of respiratory failure, need of mechanical ventilation and time of recovery following treatment were also recorded. Severity of weakness was divided into mild (grade 4), moderate (grade 2–3) and severe (grade 0–1), based on maximum muscle power in the limbs. The laboratory data such as blood counts, ESR, hemoglobin, blood sugar, serum creatinine, bilirubin, SGPT, albumin, sodium, potassium, calcium and magnesium were also noted. The etiology of HPP was defined by arterial blood gas, blood pH, serum electrolyte, anion gap, thyroid function test and urinary pH and electrolytes. Thyrotoxicosis was defined as TSH (thyroid stimulating hormone) <0.3 mIU/L and free T4 >25.7 pmol/L or T3 >2.8 nmol/L and T4 >160 nmol/L; and subclinical hyperthyroidism as TSH <0.3 mIU/L and normal free T4 or normal T3 and T4 after excluding sick euthyroid syndrome or any drug effect. The clinical and biochemical parameters of the patients with idiopathic periodic paralysis and TTP were compared by Chi square test, Fisher exact test, independent t test and Mann-Whitney U test by using the Version 15 software. The variables having a two-tailed P-value of <0.05 were considered significant.


Results

During the study period, there were 52 patients with HPP, which comprised of TPP in nine (17.3%), renal tubular acidosis-I in seven (13.5%), Gitelman syndrome in five (9.6%), Conn's syndrome in three (5.8%), renal tubular acidosis-II in one (1.9%) and IHPP in 27 (52%) [Figure 1].

Thyrotoxic periodic paralysis

The mean age of the patients with TPP was 33.6 (22–48) years, and only one was a female. The mean duration of illness was 9.6 months (1 day to 60 months) since first attack of periodic paralysis. Four patients had one attack, one had two attacks and four had three or more attacks of paralysis. Most of the patients were admitted during the spring (two patients) or summer (four patients) months and none during the winter months. The precipitating factors for muscle weakness were high-carbohydrate meal in two and preceding febrile illness in one patient. None had physical stress or alcohol as a precipitating factor. Five patients had tachycardia on admission and the pulse rate ranged between 110 and 126/min. One patient had hypertension. The severity of weakness was variable, and ranged from mild to severe weakness. On admission, severe weakness (grade 0–1) was present in four, moderate (grade 2–3) in two and mild (grade 4) in three patients. Bulbar weakness was present in two patients, which was evidenced by nasal regurgitation, nasal intonation, swallowing difficulty, weak gag reflex and normal pharyngeal sensation. Both the patients also had respiratory distress, but did not require mechanical ventilation. None of the patients had facial or ocular involvement. Kidney and liver function tests were normal in all. Mean serum potassium level was 2.21 (1.44–3.4) mEq/L; two patients had serum potassium level below 2 mEq/L. Serum phosphorous was reduced in seven and serum magnesium was normal in all. Serum TSH was low in all, ranging from <0.01 to 0.15 mIU/L. Only one patient was already diagnosed case of hyperthyroidism prior to the occurrence of TPP. Five patients had symptoms of thyrotoxicosis on admission. Toxic nodular goiter was present in one, Grave's disease in two, diffuse toxic goiter in two, colloid goiter in one and thyroiditis in one patient. Subclinical thyrotoxicosis was present in four patients. The etiology of hyperthyroidism could not be determined in two patients. Subclinical hyperthyroidism was present in two patients.

The patients were treated with potassium supplementation; five patients were treated with oral and four with intravenous potassium. The patients recovered within a mean duration of 34 (18–48) h. Rebound hyperkalemia (>5.5 meq/L) occurred in three patients during treatment; one also had >6.5 meq/L. None had cardiac arrhythmia or worsening of muscular weakness due to hyperkalemia. The referral diagnosis of the patients with TPP was Guillain-Barre syndrome in three, HPP in four and hysterical weakness in one patient. One patient received acetazolamide for prophylaxis on the advice of the primary physician. Demographic, clinical and salient laboratory features are summarized in Table 1.

Comparison of thyrotoxic periodic paralysis with idiopathic hypokalemic periodic paralysis

The demographic and clinical variables such as precipitating factors, presence of myalgia, number of attacks and severity of weakness were not statistically different between the two groups. None of the patients with IHPP had tachycardia. Respiratory involvement was present in six and bulbar weakness in four patients with idiopathic hypokalemic paralysis; two of these patients required artificial ventilation. Serum potassium level was significantly lower in TPP (2.21 ± 0.49 mEq/L) compared with IHPP (2.67 ± 0.59 mEq/L, P = 0.04). During treatment, eight patients developed rebound hyperkalemia; one had serum potassium level >6.5 mEq/L and four had in between 6 and 6.5 mEq/L. The frequency of hyperkalemia between IHPP and TPP was similar (P = 0.70). The recovery was faster in the IHPP (26.72 ± 15.35 h) compared with the TPP group (34.0 ± 14.03 h), although this difference is not statistically significant (P = 0.30). One patient in the IHPP group died because of respiratory failure with complications of mechanical ventilation, but no deaths were reported in the TPP group. The comparison of demographic and clinical parameters in TPP and IHPP is presented in Table 2.


Discussion

In our study, nine of 52 (17.3%) patients with HPP had TPP, and two-thirds of them had subclinical thyrotoxicosis/hyperthyroidism. The demographic and clinical variables as well as rebound hyperkalemia were not statistically different between the TPP and the IHPP groups. TPP is thought to be common in Oriental Asian males. It has been reported mainly from China, Japan, Korea, Taiwan and Singapore.[2, 3, 11, 12] The incidence of TPP in these regions ranges between 8% and 13% in males and 0.2% and 0.4% in females. Thyrotoxicosis however is common in females, but TPP in more common in males. The male to female ratio varies from 17:1 to 20:1 in Japan, 33:1 to 48:1 in the USA and 44:1 to 76:1 in China.[24] This figure is 8:1 in our study. A lower male to female ratio in our study may be because of the small sample size or difference in ethnicity. The commonness of TPP in males may be due to the influence of androgen in potassium homeostasis. Association of TPP in two patients with adrenal adenoma having hyperandrogenemia has been reported. It was postulated that androgen may have triggered TPP by inducing sodium potassium ATPase activity.[13] TPP has also been reported from western countries, especially in American Indians and Hispanics.[4, 14] These reports are attributed to migration of the oriental population. From India, the present report is the largest series on TPP.

TPP commonly occurs in the age group of 20–40 years; the mean age of our patients is also 33.6 (24–48) years.[2, 15] Patients with TPP have variable weakness, which may be precipitated by high carbohydrate meal, physical exertion, preceding febrile illness and, often, on getting up from the sleep, similar to patients with IHPP.[16] In the present study, heavy carbohydrate meal and febrile illness were the precipitating factors in the TPP group, while heavy exercise and alcohol were the precipitating factors in the IHPP group. Seasonal variation of TPP attacks has been reported from China and in few other studies.[2, 12] It has been attributed to increased consumption of sweet drinks, outdoor activities, exercise and increased potassium loss in sweat during the summer months. In our study, most of the patients with TPP were also admitted during the spring and summer months. Bulbar weakness in TPP has not been reported, although acute bulbar paralysis in the patients with thyrotoxicosis has reported in some patients who improved over weeks following treatment of thyrotoxicosis but not following potassium infusion.[17, 18] Both our patients with bulbar weakness however improved completely after potassium infusion along with the improvement in limb power, suggesting a relationship of bulbar weakness and hypokalemia. Acute respiratory failure in a 29-year-old male with TPP has been reported, whose plasma potassium was 3 mmol/L. He improved following potassium infusion and was weaned from the ventilator after 14 h.[19] Bulbar weakness and respiratory paralysis have also been reported in a patient with severe HPP due to renal tubular acidosis. His neurological conditions improved following correction of potassium.[20] Two of our patients with TPP had respiratory compromise, but did not require artificial ventilation. The serum potassium level in our TPP group was lower than in the IHPP group. In TPP, there is a shift of potassium ion into the cells rather than loss of potassium.[6] This may result in very low serum potassium and may produce life-threatening paralysis and cardiac arrhythmias. Serum phosphorus also may be reduced during the attack, and was low in seven of our patients.[21] Patients with TPP may be confused with GB syndrome, renal tubular acidosis and IHPP. In our study, one patient was inadvertently diagnosed as GB syndrome and was treated with IVIg by the primary physician and another with acetazolamide for prophylaxis of suspected IHPP. Acetazolamide aggravates muscle weakness in patients with TPP. The comparison of TPP and IHPP in a study revealed that patients with IHPP presenting before the age of 20 years may have a family history and that serum potassium levels are not very low.[22] Severe hypokalemia in periodic paralysis suggests an underlying secondary cause.[10] In our study, the demographic and clinical features were not significantly different in both the groups, except serum potassium, which was lower in the TPP group compared with the IHPP group.

The thyrotoxic symptoms may be absent at the time of attack of TPP in 10–25% of the patients.[5, 12] In our study, two-thirds of the patients with TPP had subclinical thyrotoxicosis/hyperthyroidism at the time of presentation. This makes diagnosis of TPP more challenging. A high index of suspicion is needed for the diagnosis of TPP, especially in a young to middle aged male of Asian ethnicity who develops hypokalemia and paralysis. Occurrence and severity of TPP does not depend on severity and etiology of thyrotoxicosis.[12] In our study, the cause of thyrotoxicosis could be ascertained in seven patients, which were toxic nodular goiter, Grave's disease, diffuse toxic goiter, colloid goiter and thyroiditis. Etiology of hyperthyroidism could not be determined in two of our patients.

Treatment of TPP is oral or intravenous potassium supplementation, depending on the severity of weakness and to prevent recurrence. Nonselective beta blockers and correction of thyrotoxicosis are recommended. Rebound hyperkalemia has been reported in TPP and sporadic HPP during treatment. Fatal cardiac arrhythmia has been reported secondary to rebound hyperkalemia in TPP.[23] It is important to monitor the serum potassium during treatment to avoid such complications. In our study, three patients with TPP and eight with IHPP had rebound hyperkalemia. None of the patients however had complications of rebound hyperkalemia. In our patients, propranolol and neomarcazole were prescribed to all. Radioactive iodine or surgery was performed later depending on the severity of the thyrotoxicosis and patient preference. Correction of thyrotoxicosis is important for preventing the recurrent attacks of paralysis. The limitations of the present study are its retrospective nature, having been performed in a neurology setting and long-term follow-up not being available.


Conclusion

It can be concluded from this study that TPP comprises about 17.3% of HPP. All the patients with HPP should be investigated for thyrotoxicosis because management of thyrotoxicosis prevents attacks of TPP.


Notes

Source of Support: Nil

Conflict of Interest: Nil

The authors acknowledge Mr. Rakesh Kumar Nigam for secretarial help.


References
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13. Biering H,Bauditz J,Pirlich M,Lochs H,Gerl H. Manifestation of thyrotoxic periodic paralysis in two patients with adrenal adenomas and hyperandrogenaemiaHorm ResYear: 200359301412784096
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17. Mathew B,Devasia AJ,Ayyar V,Thyagaraj V,Francis GA. Thyrotoxicosis presenting as acute bulbar palsyJ Assoc Physicians IndiaYear: 201159386721751598
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Figures

[Figure ID: F1]
Figure 1 

Etiology of hypokalemic periodic paralysis



Tables
[TableWrap ID: T1] Table 1 

Clinical and laboratory findings of patients with thyrotoxic periodic paralysis



[TableWrap ID: T2] Table 2 

Comparison of demographic, clinical, biochemical and outcome profile between idiopathic hypokalemic periodic paralysis and thyrotoxic periodic paralysis




Article Categories:
  • Original Article

Keywords: Hypokalemia, hypokalemic periodic paralysis, periodic paralysis, thyrotoxic periodic paralysis, treatment.

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