| Comparative study on sustained release of human growth hormone from semi-crystalline poly(L-lactic acid) and amorphous poly(D,L-lactic-co-glycolic acid) microspheres: morphological effect on protein release. | |
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MedLine Citation:
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PMID: 15245894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recombinant human growth hormone (rhGH) was encapsulated by a double emulsion solvent evaporation method within two biodegradable microspheres having different polymer compositions. Semi-crystalline poly(L-lactic acid) (PLA) and amorphous poly(D,L-lactic-co-glycolic acid) (PLGA) were used for the encapsulation of hGH. Protein release profiles from the two microspheres were comparatively evaluated with respect to their morphological difference. Both of the microspheres similarly exhibited rugged surface and porous internal structures, but their inner pore wall morphologies were quite different. The slowly degrading PLA microspheres had many nano-scale reticulated pores on the wall, while the relatively fast degrading PLGA microspheres had a non-porous and smooth wall structure. From the PLA microspheres, hGH was released out in a sustained manner with an initial approximately 20% burst, followed by constant release, and almost 100% complete release after a 1-month period. In contrast, the PLGA microspheres showed a similar burst level of approximately 20%, followed by much slower release, but incomplete release of approximately 50% after the same period. The different hGH release profiles between PLA and PLGA microspheres were attributed to different morphological characters of the pore wall structure. The inter-connected nano-porous structure of PLA microspheres was likely to be formed due to the preferable crystallization of PLA during the solvent evaporation process. |
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Authors:
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Hong Kee Kim; Tae Gwan Park |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 98 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-12 Completed Date: 2005-01-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: 115-25 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Kuseong-dong Yuseong-gu, Daejeon, 305-701, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Delayed-Action Preparations
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chemistry,
pharmacokinetics Human Growth Hormone / chemistry*, pharmacokinetics Humans Lactic Acid / chemistry*, pharmacokinetics Microspheres* Polyglycolic Acid / chemistry*, pharmacokinetics Polymers / chemistry*, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 12629-01-5/Human Growth Hormone; 26009-03-0/Polyglycolic Acid; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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