| Comparative study of standard space and real space analysis of quantitative MR brain data. | |
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MedLine Citation:
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PMID: 21591021 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To compare the robustness of region of interest (ROI) analysis of magnetic resonance imaging (MRI) brain data in real space with analysis in standard space and to test the hypothesis that standard space image analysis introduces more partial volume effect errors compared to analysis of the same dataset in real space. MATERIALS AND METHODS: Twenty healthy adults with no history or evidence of neurological diseases were recruited; high-resolution T(1) -weighted, quantitative T(1) , and B(0) field-map measurements were collected. Algorithms were implemented to perform analysis in real and standard space and used to apply a simple standard ROI template to quantitative T(1) datasets. Regional relaxation values and histograms for both gray and white matter tissues classes were then extracted and compared. RESULTS: Regional mean T(1) values for both gray and white matter were significantly lower using real space compared to standard space analysis. Additionally, regional T(1) histograms were more compact in real space, with smaller right-sided tails indicating lower partial volume errors compared to standard space analysis. CONCLUSION: Standard space analysis of quantitative MRI brain data introduces more partial volume effect errors biasing the analysis of quantitative data compared to analysis of the same dataset in real space. J. Magn. Reson. Imaging 2011;33:1503-1509. © 2011 Wiley-Liss, Inc. |
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Authors:
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Benjamin S Aribisala; Jiabao He; Andrew M Blamire |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 33 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1503-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Institute of Cellular Medicine and Newcastle Magnetic Resonance Centre, Newcastle University, United Kingdom. B.S.Aribisala@newcastle.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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