| Comparative study on secondary structural changes in diabetic and non-diabetic human finger nail specimen by using FTIR spectra. | |
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MedLine Citation:
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PMID: 21093422 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: In human anatomy, a nail is a hornlike envelope covering the dorsal aspect of the terminal phalanges of fingers and toes. Nail disorders are most common among the geriatric population. Diabetes mellitus is also supposed to affect the condition of nails. Acceptable differences in infrared (IR) spectra of chronic and acute diabetes mellitus patient fingernail specimens compared to control normal specimens were investigated in this study. METHODS: Using a Nicolet 360 Fourier Transform Infra Red (FTIR) spectrometer, the spectra of the nails of diabetics and normal specimens were recorded. RESULT: In the case of non-diabetic patients, the amide I band was observed <1640 cm(-1) (1626, 1632, and 1638 cm(-1)). The bands around 1637 cm(-1), were attributable to amide I of β sheet structures. Amide II bands were absent in all the non-diabetic patients. Amide III bands around 1250 cm(-1) were observed both in diabetic and non-diabetic patients. In all the diabetic patients, a peak of <500 cm(-1), particularly around 468 cm(-1), was observed. CONCLUSION: The proteins in the nails of diabetic patients contain α-helical structure, including the presence of amide II bonds. Alkyl thiolated structures are observed. Nails of non-diabetic patients do not have the amide II structures. |
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Authors:
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Katheem M Farhan; Thottapalli P Sastry; Asit B Mandal |
Publication Detail:
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Type: Journal Article Date: 2010-11-18 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 412 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 386-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Bio-Products Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research (CSIR), Adyar, Chennai, 600020, Tamilnadu, India. |
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