Document Detail

Comparative study on the properties of saturated phosphatidylethanolamine and phosphatidylcholine bilayers: barrier characteristics and susceptibility to phospholipase A2 degradation.
MedLine Citation:
PMID:  7139847     Owner:  NLM     Status:  MEDLINE    
comparative studies on bilayer systems of saturated phosphatidylcholines and phosphatidylethanolamines revealed a maximum in ionic permeability in phosphatidylcholine bilayers at the temperature of the gel to liquid-crystalline phase transition but such an increase in permeability was not detectable in bilayers of phosphatidylethanolamine. Furthermore, it was found that at the phase transition temperature the phosphatidylcholine bilayers are subject to rapid hydrolysis by pancreatic phospholipase A2 whereas phosphatidylethanolamine bilayers are not. These differences are discussed in view of detailed information on the molecular organization in the gel and liquid crystalline phases of the two phospholipid classes.
P C Noordam; A Killian; R F Oude Elferink; J De Gier
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  31     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  191-204     Citation Subset:  IM    
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MeSH Terms
Freeze Fracturing
Lipid Bilayers*
Molecular Conformation
Phosphatidylcholines* / metabolism*
Phosphatidylethanolamines* / metabolism
Phospholipases / metabolism*
Phospholipases A / metabolism*
Phospholipases A2
Spectrum Analysis, Raman
Surface Properties
Reg. No./Substance:
0/Lipid Bilayers; 0/Liposomes; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; EC 3.1.-/Phospholipases; EC 3.1.1.-/Phospholipases A; EC A2

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