| A COMPARATIVE STUDY OF PREOPERATIVE IMAGING METHODS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM: US, MIBI, SPECT AND MRI. | |
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MedLine Citation:
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PMID: 21623148 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: This study compares the accuracy rates achieved in ultrasonography (US), 99mTcsestamibi (MIBI), single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) as imaging methods used in the preoperative localization of the enlarged parathyroid glands. Subjects and Methods: For the purposes of this study, US, MIBI, SPECT and MRI were performed on ninety-eight patients with primary hyperparathyroidism (pHPT). All patients underwent parathyroidectomy. Results: Preoperative localisation of an abnormal parathyroid gland was successfully performed in 82 of the cases scanned with US (83.7%), while the result was 66 in the cases scanned with MIBI (67.3%), 71 of the cases were successfully localised with SPECT (72.4%), while MRI revealed the diseased gland in only 60 of the total cases (61.2%). In MIBI positive and negative patients there was a statistically significant difference among cases in terms of adenoma volume (1.30±1.51 vs. 0.58±0.91, p < 0.05). Sensitivity, specificity and diagnostic accuracy values were 87.2%, 25.0%, and 83.0%; 70.2%, 50.0%, and 69.4%; 75.5%, 50.0%, and 74.5%; 63.8%, 50.0%, and 63.3% for US, MIBI, SPECT and MRI, respectively. The respective values for sensitivity, specificity and diagnostic accuracy were 94.9%, 25.0% and 91.1% when US was combined with MIBI. Conclusions: Combining US and MIBI as imaging methods for preoperative imaging of pHPT often produces more satisfactory results. While the accuracy of US is relatively low in the ectopic localizations, the size of the lesion can be an important factor in the accuracy achieved with MIBI. |
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Authors:
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Gulhan Akbaba; Dilek Berker; Serhat Isik; Yusuf Aydin; Deniz Ciliz; Irfan Peksoy; Ufuk Ozuguz; Yasemin Ates Tutuncu; Serdar Guler |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-27 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Ministry of Health, Ankara Numune Research and Training Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey. gulhanakcil@yahoo.com.tr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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