| Comparative study and optimisation of the administration mode of three proton pump inhibitors by nasogastric tube. | |
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MedLine Citation:
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PMID: 15990258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients in intensive care often develop stress-induced ulcers. As a preventive measure, proton pump inhibitors (PPIs) are administered by nasogastric tube. However, some PPIs can block the tube. The aim of this study was to compare the behaviour of three PPIs (omeprazole, lanzoprazole and esomeprazole) during the transit of the granules through the tube and to optimise their modes of administration. For each IPP, the experiment was designed to study the influence of four variables: the tube material (silicone or polyurethane), the solvent used to dilute the granules (water or apple juice), the mode of administration (in two or three doses) and the rinse volume (10 or 20 ml). We counted the granules before transit and at the tube outlet, and assayed the active drug ingredient by UV spectrometry. The assay showed complete transit of esomeprazole through the tube, but average losses of omeprazole and lanzoprazole of 39 and 33%, respectively, were observed. No significant improvement was obtained by the variables 'diluent' and 'mode of administration'. The variable 'rinse' had a significant influence. For lanzoprazole, a polyurethane tube allowed recovery of on average 86% of the active ingredient. Esomeprazole is thus the choice PPI for the treatment of patients by nasogastric tube. Using a polyurethane tube and a rinse volume of 20 ml, the administration of lanzoprazole by tube can be considered. Use of omeprazole is not recommended because none of the modes of administration tested ensured that a sufficient concentration of active ingredient reached the stomach. |
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Authors:
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D Messaouik; V Sautou-Miranda; S Bagel-Boithias; J Chopineau |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 299 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-18 Completed Date: 2006-02-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 65-72 Citation Subset: IM |
Affiliation:
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Service Pharmacie, Hôpital G. Montpied, Rue Montalembert, BP69, 63003 Clermont-Ferrand, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles Anti-Ulcer Agents / chemistry* Beverages Intubation, Gastrointestinal / methods* Malus Omeprazole / analogs & derivatives, chemistry Particle Size Polyurethanes Proton Pumps / antagonists & inhibitors* Rheology Silicones Solvents Water |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Polyurethanes; 0/Proton Pumps; 0/Silicones; 0/Solvents; 103577-45-3/lansoprazole; 73590-58-6/Omeprazole; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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