Document Detail


Comparative study of nifedipine and isoxpurine as tocolytics for preterm labor.
MedLine Citation:
PMID:  23024518     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study was done to compare isoxpurine hydrochloride and nifedipine as tocolytic drugs for preterm labor.
METHODS: A prospective cohort study of 832 antenatal women with preterm labor was conducted in the Department of Obstetrics & Gynecology. Out of 400 women found eligible for tocolysis, 200 were given isoxpurine hydrochloride while the other 200 were given nifedipine randomly. The data obtained was statistically analyzed on SPSS 10.0 of Windows 2003.
RESULTS: Incidence of preterm labor was 22% while the incidence of preterm delivery was 20.9%. Nifedipine was twice more effective than isoxpurine hydrochloride as a tocolytic agent as a tocolytic agent (P value 0.006) while side effects were comparable (P value 0.133). In early-diagnosed preterm labor, nifedipine had higher efficacy than isoxpurine (P value 6.45 × 10(-6)) and also higher efficacy than its own in late diagnosed preterm labor (P value 2.08 × 10(-5)).
CONCLUSIONS: There is a high incidence of preterm labor in India. Nifedipine is a better tocolytic drug than isoxpurine hydrochloride, especially when started with the earliest signs of preterm labor.
Authors:
Nisha Singh; Uma Singh; Shikha Seth
Related Documents :
1285508 - Survival rate of extremely low birthweight infants and its effect on the amendment of t...
23583838 - Outcomes of infants exposed to oseltamivir or zanamivir in utero during pandemic (h1n1)...
1879108 - Neonatal candidiasis: the current challenge.
18201808 - The contribution of maternal working conditions to socio-economic inequalities in birth...
19929798 - Transplacental transfer of antiretroviral drugs and newborn birth weight in hiv-infecte...
2589278 - Regulation of oxygen concentration delivered to infants via nasal cannulas.
Publication Detail:
Type:  Journal Article     Date:  2011-10-29
Journal Detail:
Title:  Journal of obstetrics and gynaecology of India     Volume:  61     ISSN:  0975-6434     ISO Abbreviation:  J Obstet Gynaecol India     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0374763     Medline TA:  J Obstet Gynaecol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  512-5     Citation Subset:  -    
Affiliation:
Department of Obstetrics & Gynecology, CSM Medical University (former KGMC), A-172 South City, Lucknow, UP India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Placental insufficiency and fetal growth restriction.
Next Document:  Premature Rupture of Membranes at Term: Immediate Induction With PGE(2) Gel Compared With Delayed In...