| Comparative study of the levels of sialyltransferases responsible for the formation of sugar chains in glycoproteins and gangliosides in rat liver and hepatomas. | |
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MedLine Citation:
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PMID: 3137201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sialyltransferases responsible for the formation of sugar chains in glycoproteins were studied in rat hepatoma in comparison with rat liver. Hepatoma induced by feeding Wistar rats with 3'-methyl-4-dimethylaminoazobenzene (MeDAB) was more active than Wistar liver in sialylating asialo-orosomucoid, and this was due to an increased activity of Gal(beta 1----4)GlcNAc (alpha 2----6) sialyltransferase, the major sialyltransferase in these tissues. Gal(beta 1----3,4)GlcNAc (alpha 2----3) sialyltransferase and the sialyltransferase acting on asialo-bovine submaxillary mucin were, however, decreased in the hepatoma. A similar pattern of sialyltransferase alterations was observed in regenerating liver and other tumors such as AH-109A hepatoma and Sato lung cancer, both of which had been inoculated into Donryu rats. In contrast to these sialyltransferases, the activities of the sialyltransferases responsible for the formation of gangliosides were markedly different even between Wistar and Donryu livers. When compared with Wistar liver, MeDAB-induced hepatoma was higher in lactosylceramide- and lower in GM3-sialyltransferase activity, but these two activities were both lower in AH-109A compared with Donryu liver. |
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Authors:
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T Miyagi; M Koseki; S Tsuiki |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese journal of cancer research : Gann Volume: 79 ISSN: 0910-5050 ISO Abbreviation: Jpn. J. Cancer Res. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-10-06 Completed Date: 1988-10-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8509412 Medline TA: Jpn J Cancer Res Country: JAPAN |
Other Details:
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Languages: eng Pagination: 742-9 Citation Subset: IM |
Affiliation:
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Research Institute for Tuberculosis and Cancer, Tohoku University, Sendai. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gangliosides / metabolism* Glycolipids / metabolism Glycoproteins / metabolism* Liver / enzymology* Liver Neoplasms, Experimental / chemically induced, enzymology* Lung Neoplasms / enzymology Male Methyldimethylaminoazobenzene Oligosaccharides / metabolism Rats Rats, Inbred Strains Sialyltransferases / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Gangliosides; 0/Glycolipids; 0/Glycoproteins; 0/Oligosaccharides; 55-80-1/Methyldimethylaminoazobenzene; EC 2.4.99.-/Sialyltransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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