Document Detail


Comparative study of invasive squamous cell carcinoma and verrucous carcinoma of the oral cavity: expression of bcl-2, p53, and Her-2/neu, and indexes of cell turnover.
MedLine Citation:
PMID:  9398988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant clinical and biological differences are found between invasive squamous cell carcinoma (SCCA) and verrucous carcinoma (VC) of the oral cavity. The correct diagnosis of these tumors has important therapeutic implications. Immunoperoxidase stains for bcl-2, p53, and Her-2/neu, and in situ end-labeling of DNA to identify apoptosis were performed in eight VC and eight SCCA matched for age, sex, and stage. Marked differences were identified in the pattern of expression of oncogenes and the indexes of cell turnover in these two types of tumors. VC displayed minimal apoptosis in rare keratinizing cells (0 to 3%); p53-positive cells (4/8) and Ki-67 (8/8) were confined to the nuclei of the basal proliferating layers; and bcl-2 (4/8) was expressed only in the cytoplasm of rare tumor cells. In contrast, SCCA displayed higher apoptosis rates (5 to 10%), whereas p53- (5/8) and Ki-67- (8/8) positive nuclei were distributed randomly throughout the tumor. Very well differentiated areas in one SCCA case had a pattern of staining for p53 and Ki-67 similar to the one seen in VC. In SCCA bcl-2 showed patchy cytoplasmic staining (4/8) or strong cytoplasmic and nuclear positivity (2/8) in the less differentiated tumors. Her-2/neu was negative in all VC and SCCA cases. The different levels and patterns of gene expression and cell turnover between SCCA and VC undoubtedly correlate with the different biology and prognosis of these tumors.
Authors:
C B Drachenberg; R Blanchaert; O B Ioffe; R A Ord; J C Papadimitriou
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer detection and prevention     Volume:  21     ISSN:  0361-090X     ISO Abbreviation:  Cancer Detect. Prev.     Publication Date:  1997  
Date Detail:
Created Date:  1997-12-31     Completed Date:  1997-12-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704778     Medline TA:  Cancer Detect Prev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-9     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Apoptosis* / genetics
Carcinoma, Squamous Cell / genetics*,  metabolism,  pathology
Carcinoma, Verrucous / genetics*,  metabolism,  pathology
Female
Gene Expression*
Genes, bcl-2 / genetics*
Genes, erbB-2 / genetics*
Humans
Immunoenzyme Techniques
Ki-67 Antigen / analysis
Male
Middle Aged
Mouth Neoplasms / genetics*,  metabolism,  pathology
Tumor Suppressor Protein p53 / genetics*
Chemical
Reg. No./Substance:
0/Ki-67 Antigen; 0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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