| Comparative study of intravaginal metronidazole and triple-sulfa therapy for bacterial vaginosis. | |
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MedLine Citation:
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PMID: 18476069 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to compare the efficacy of metronidazole gel vs. triple-sulfa cream in the treatment of bacterial vaginosis (BV). METHODS: In a double-blinded study, 247 women with symptomatic BV were randomly assigned to receive either 5 g of 0.75% metronidazole gel twice daily for 5 days or triple-sulfa cream twice daily for 5 days. There were 205 (96 treated with metronidazole and 109 treated with triple-sulfa) evaluable patients to compare efficacy at the final visit. Approximately 60% of these patients had been previously treated for BV, reflecting the recurrent nature of the disease in this patient population. RESULTS: At the first (12-16 days) return visit, 81/103 (79%) patients in the metronidazole group were cured compared with 80/113 (71%) patients in the triple-sulfa cream group (P = 0.333). At the final (28-35 days) return visit, 63/96 (66%) in the 96 metronidazole group remained cured compared with only 51/109 (47%) in the triple-sulfa group (P = 0.02). An intent-to-treat analysis similarly showed that the cure rate with metronidazole was superior to triple-sulfa (P < or = 0.02). The clinical diagnosis demonstrated a high correlation (88%) with the diagnosis made by an independent assessment by Gram's stain. The side effects reported by the patients using metronidazole gel were infrequent and mild and were similar to those reported with triple-sulfa. CONCLUSIONS: Metronidazole gel is a safe, effective, and well-tolerated treatment for BV. |
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Authors:
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J D Sobel; W Chaim; J Thomason; C Livengood; R Sweet; J A McGregor; D Eschenbach; S Hillier; R Galask; S Faro; E Shangle; D Baker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infectious diseases in obstetrics and gynecology Volume: 4 ISSN: 1064-7449 ISO Abbreviation: Infect Dis Obstet Gynecol Publication Date: 1996 |
Date Detail:
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Created Date: 2008-05-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9318481 Medline TA: Infect Dis Obstet Gynecol Country: Egypt |
Other Details:
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Languages: eng Pagination: 66-70 Citation Subset: - |
Affiliation:
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Department of Medicine and Obstetrics and Gynecology Wayne State University School of Medicine, Detroit, MI, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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Journal Information Journal ID (nlm-ta): Infect Dis Obstet Gynecol ISSN: 1064-7449 ISSN: 1098-0997 Publisher: Hindawi Publishing Corporation |
Article Information Download PDF  Copyright ? 1996 Hindawi Publishing Corporation. open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received Day: 11 Month: 12 Year: 1995 Accepted Day: 29 Month: 5 Year: 1996 Print publication date: Year: 1996 Volume: 4 Issue: 2 First Page: 66 Last Page: 70 ID: 2364475 PubMed Id: 18476069 Publisher Item Identifier: S1064744996000154 DOI: 10.1155/S1064744996000154 |
| Comparative Study of Intravaginal Metronidazole and Triple-Sulfa Therapy for Bacterial Vaginosis | |
| Jack D. Sobel112 | |
| Walter Chaim1 | |
| Jessica Thomason2 | |
| Charles Livengood3 | |
| Richard Sweet4 | |
| James A. McGregor5 | |
| David Eschenbach6 | |
| Sharon Hillier7 | |
| Rudolph Galask8 | |
| Sebastian Faro9 | |
| Elizabeth Shangle10 | |
| David Baker11 | |
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1Department of Medicine and Obstetrics and GynecologyWayne State University School of MedicineDetroitMIUSA |
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2Department of Obstetrics and GynecologySinai Samaritan Medical CenterMilwaukeeWIUSA |
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3Department of Obstetrics and GynecologyDuke University Medical CenterDurhamNCUSA |
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4Department of Obstetrics and GynecologySan Francisco General HospitalSan FranciscoCAUSA |
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5Department of Obstretrics and GynecologyUniversity of ColoradoDenverCOUSA |
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6Department of Obstetrics and GynecologyUniversity of WashingtonSeattleWAUSA |
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7Department of Obstetrics, Gynecology and Reproductive SciencesUniversity of PittsburghPittsburghPAUSA |
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8Department of Obstetrics and GynecologyUniversity of Iowa Hospitals and ClinicsIowa CityIAUSA |
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9Department of Gynecology and ObstetricsUniversity of Kansas School of MedicineKansas CityKSUSA |
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10Department of Obstetrics and GynecologyLoyola University Medical CenterMaywoodILUSA |
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11Department of Obstetrics and GynecologySUNY Health Science CenterStony BrookNYUSA |
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12Harper Professional BuildingSuite 21404160 John R StreetDetroitMI48201USA |
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