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Comparative study of intravaginal metronidazole and triple-sulfa therapy for bacterial vaginosis.
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MedLine Citation:
PMID:  18476069     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: We sought to compare the efficacy of metronidazole gel vs. triple-sulfa cream in the treatment of bacterial vaginosis (BV).
METHODS: In a double-blinded study, 247 women with symptomatic BV were randomly assigned to receive either 5 g of 0.75% metronidazole gel twice daily for 5 days or triple-sulfa cream twice daily for 5 days. There were 205 (96 treated with metronidazole and 109 treated with triple-sulfa) evaluable patients to compare efficacy at the final visit. Approximately 60% of these patients had been previously treated for BV, reflecting the recurrent nature of the disease in this patient population.
RESULTS: At the first (12-16 days) return visit, 81/103 (79%) patients in the metronidazole group were cured compared with 80/113 (71%) patients in the triple-sulfa cream group (P = 0.333). At the final (28-35 days) return visit, 63/96 (66%) in the 96 metronidazole group remained cured compared with only 51/109 (47%) in the triple-sulfa group (P = 0.02). An intent-to-treat analysis similarly showed that the cure rate with metronidazole was superior to triple-sulfa (P < or = 0.02). The clinical diagnosis demonstrated a high correlation (88%) with the diagnosis made by an independent assessment by Gram's stain. The side effects reported by the patients using metronidazole gel were infrequent and mild and were similar to those reported with triple-sulfa.
CONCLUSIONS: Metronidazole gel is a safe, effective, and well-tolerated treatment for BV.
Authors:
J D Sobel; W Chaim; J Thomason; C Livengood; R Sweet; J A McGregor; D Eschenbach; S Hillier; R Galask; S Faro; E Shangle; D Baker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infectious diseases in obstetrics and gynecology     Volume:  4     ISSN:  1064-7449     ISO Abbreviation:  Infect Dis Obstet Gynecol     Publication Date:  1996  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9318481     Medline TA:  Infect Dis Obstet Gynecol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  66-70     Citation Subset:  -    
Affiliation:
Department of Medicine and Obstetrics and Gynecology Wayne State University School of Medicine, Detroit, MI, USA.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Infect Dis Obstet Gynecol
ISSN: 1064-7449
ISSN: 1098-0997
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright ? 1996 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 11 Month: 12 Year: 1995
Accepted Day: 29 Month: 5 Year: 1996
Print publication date: Year: 1996
Volume: 4 Issue: 2
First Page: 66 Last Page: 70
ID: 2364475
PubMed Id: 18476069
Publisher Item Identifier: S1064744996000154
DOI: 10.1155/S1064744996000154

Comparative Study of Intravaginal Metronidazole and Triple-Sulfa Therapy for Bacterial Vaginosis
Jack D. Sobel112
Walter Chaim1
Jessica Thomason2
Charles Livengood3
Richard Sweet4
James A. McGregor5
David Eschenbach6
Sharon Hillier7
Rudolph Galask8
Sebastian Faro9
Elizabeth Shangle10
David Baker11
1Department of Medicine and Obstetrics and GynecologyWayne State University School of MedicineDetroitMIUSA
2Department of Obstetrics and GynecologySinai Samaritan Medical CenterMilwaukeeWIUSA
3Department of Obstetrics and GynecologyDuke University Medical CenterDurhamNCUSA
4Department of Obstetrics and GynecologySan Francisco General HospitalSan FranciscoCAUSA
5Department of Obstretrics and GynecologyUniversity of ColoradoDenverCOUSA
6Department of Obstetrics and GynecologyUniversity of WashingtonSeattleWAUSA
7Department of Obstetrics, Gynecology and Reproductive SciencesUniversity of PittsburghPittsburghPAUSA
8Department of Obstetrics and GynecologyUniversity of Iowa Hospitals and ClinicsIowa CityIAUSA
9Department of Gynecology and ObstetricsUniversity of Kansas School of MedicineKansas CityKSUSA
10Department of Obstetrics and GynecologyLoyola University Medical CenterMaywoodILUSA
11Department of Obstetrics and GynecologySUNY Health Science CenterStony BrookNYUSA
12Harper Professional BuildingSuite 21404160 John R StreetDetroitMI48201USA


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