Document Detail

Comparative study of the haemodynamic effects of oral molsidomine and isosorbide dinitrate in man.
MedLine Citation:
PMID:  6897039     Owner:  NLM     Status:  MEDLINE    
The haemodynamic effects of oral molsidomine 4 mg and sustained-release isosorbide dinitrate (ISDN) 40 mg have been compared in 10 patients recovering from acute myocardial infarction. After both drugs pulmonary arterial, pulmonary capillary wedge and systemic arterial blood pressure were reduced to about the same extent. The maximum effect was reached 1.5 to 2 h after ingestion of both drugs, but the effect of molsidomine declined during the following 2 h and control values were almost reached after 4 h. After ISDN there was no rebound during the observation period of 6 h. Unlike molsidomine, ISDN reduced total peripheral resistance, so cardiac output and stroke volume index remained constant despite the reduction in cardiac preload. It is concluded that sustained release ISDN 40 mg and molsidomine 4 mg are about equieffective doses in terms of reduction of cardiac preload, but that the effect of molsidomine is of shorter duration. Since molsidomine alone causes venous pooling, cardiac output and stroke volume index are reduced, which may be an untoward side effect in patients with severe heart failure.
A Vogt; H Kreuzer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  23     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
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MeSH Terms
Cardiac Output / drug effects
Creatine Kinase / blood
Heart Rate / drug effects
Hemodynamics / drug effects*
Isosorbide Dinitrate / pharmacology*
Middle Aged
Oxadiazoles / pharmacology*
Pulmonary Circulation / drug effects
Sydnones / pharmacology*
Time Factors
Vascular Resistance / drug effects
Reg. No./Substance:
0/Oxadiazoles; 0/Sydnones; 25717-80-0/Molsidomine; 87-33-2/Isosorbide Dinitrate; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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