Document Detail

Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis.
MedLine Citation:
PMID:  1877264     Owner:  NLM     Status:  MEDLINE    
Fluconazole is a new oral triazole antifungal with good activity against Candida spp. In this study, we investigated the effectiveness and tolerability of a three-day course of treatment with fluconazole compared with clotrimazole vaginal tablets in nonpregnant women with acute Candida vaginitis. Of the 90 evaluable patients who received fluconazole, 76 (84 percent) were asymptomatic seven to ten days after treatment compared with 84 of 95 (88 percent) treated with clotrimazole. An additional ten patients in the fluconazole group (11 percent) and seven in the clotrimazole group (7 percent) had improvement in their signs and symptoms. Only four patients in each group (4 percent) were considered treatment failures. Mycological cures were obtained in 89 and 93 percent of patients treated with fluconazole and clotrimazole, respectively, seven to ten days posttreatment. Clinical cure rates remained high one month posttreatment: 79 percent in the fluconazole group and 83 percent in the clotrimazole group. Both therapies were well tolerated. One patient discontinued treatment after she developed diarrhea while receiving fluconazole. The most common adverse effects associated with fluconazole use were nausea (six percent) and diarrhea (three percent). No clinically significant laboratory abnormalities were observed. In this investigation, oral fluconazole therapy was found to be as safe and effective as clotrimazole vaginal tablets in women with acute vulvovaginal candidiasis.
G E Stein; S Christensen; N Mummaw
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  DICP : the annals of pharmacotherapy     Volume:  25     ISSN:  1042-9611     ISO Abbreviation:  DICP     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-09-25     Completed Date:  1991-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904338     Medline TA:  DICP     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  582-5     Citation Subset:  IM    
Department of Medicine, Michigan State University, East Lansing 48824.
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MeSH Terms
Administration, Intravaginal
Administration, Oral
Candidiasis, Vulvovaginal / drug therapy*
Clotrimazole / adverse effects,  therapeutic use*
Fluconazole / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Reg. No./Substance:
23593-75-1/Clotrimazole; 86386-73-4/Fluconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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