| Comparative study of epidural xylazine or clonidine in horses. | |
| | |
MedLine Citation:
|
PMID: 18275488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the cardiorespiratory and behavioural effects of epidural xylazine (XYL) or clonidine (CLO) in horses. STUDY DESIGN: Blinded, randomized experimental study. ANIMALS: Twelve healthy Arabian yearling horses weighing 117-204 kg were randomly allocated into two groups: XYL (n = 6) and CLO (n = 6). METHODS: An epidural catheter was inserted and a facial arterial catheter was placed and the next day the horses were restrained in stocks. Baseline values for heart (HR) and respiratory (RR) rates, arterial pressure and behavioural responses were evaluated before (T0) and 10, 20, 30, 45, 60, 90 and 120 minutes after epidural injection (T10-T120). The horses received 0.2 mg kg(-1) of XYL or 5 microg kg(-1) CLO; adjusted to (3.4 + (body weight in kg x 0.013) mL with saline. Data were analysed by the Kolmogorov-Smirnov test, one-way anova with repeated measures, and one-way anova followed by a Student-Newman-Keuls test or Fisher's exact test, as necessary. Significance was set at p < or = 0.05. RESULTS: Sedation and ataxia were seen at T10, persisting until T120 in four and three horses, respectively, in XYL and all horses in CLO respectively. Two XYL and one CLO horses became recumbent at T45 and T25 respectively. Penile prolapse occurred in four of five males at T30 and T45, in the XYL and CLO groups, respectively, resolving by T120. Tail relaxation was present from T10 to T120 in all horses in XYL and in four horses in CLO. Head drop was observed from T20 to T60 and from T10 to T120 in XYL and CLO respectively. Respiratory rate decreased significantly only at T45 in the CLO group. Heart rate and arterial blood pressure remained stable. CONCLUSIONS AND CLINICAL RELEVANCE: Epidural CLO and XYL produce similar cardiorespiratory and behavioural changes but neither would be safe to use clinically at the doses used in this study. |
| | |
Authors:
|
Renata G S Dória; Carlos A A Valadão; Juan C Duque; Anderson Farias; Ricardo M Almeida; Augusto Castro Netto |
Related Documents
:
|
2866788 - Effects of azepexole and clonidine on baroreceptor mediated reflex bradycardia and phys... 7011348 - Changes in blood pressure, plasma catecholamines and plasma renin activity during and a... 6353878 - Clonidine twice daily in hypertension. effects of two dosage regimens on blood pressure... 6173518 - Evaluation of a slow-release clonidine preparation by direct continuous blood pressure ... 15599118 - Roundtable discussion: blood pressure goal attainment: meeting the challenge of the jnc... 11698968 - Interstitial pressure gradients around joints; location of chief resistance to fluid dr... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Veterinary anaesthesia and analgesia Volume: 35 ISSN: 1467-2987 ISO Abbreviation: Vet Anaesth Analg Publication Date: 2008 Mar |
Date Detail:
|
Created Date: 2008-02-15 Completed Date: 2008-04-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100956422 Medline TA: Vet Anaesth Analg Country: England |
Other Details:
|
Languages: eng Pagination: 166-72 Citation Subset: IM |
Affiliation:
|
Governador Laudo Natel Veterinary Teaching Hospital, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, São Paulo, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic alpha-Agonists
/
administration & dosage,
pharmacology* Anesthesia, Epidural / veterinary* Animals Behavior, Animal / drug effects Clonidine / administration & dosage, pharmacology* Double-Blind Method Female Heart Rate / drug effects Horses / physiology* Injections, Epidural / veterinary Male Pain Measurement / drug effects, veterinary Pain, Postoperative / prevention & control, veterinary Respiration / drug effects Treatment Outcome Xylazine / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Agonists; 4205-90-7/Clonidine; 7361-61-7/Xylazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A comparison of equine recovery characteristics after isoflurane or isoflurane followed by a xylazin...
Next Document: Conflict, cheats and the persistence of symbioses.