| Comparative study of the efficacy of topical corticosteroid: five locally made and one brand name creams. | |
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MedLine Citation:
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PMID: 12296411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the efficacy of 5 locally made clobetasol propionate creams compared with a brand name product. The study was divided into 3 parts 1) pharmacological study, 2) vasoconstriction test, and 3) double blind clinical trial. The results showed that the pharmacological properties of the locally made products were not different from the brand name product. Product C and D could diffuse through cellulose acetate membrane 3 fold more than the brand name product. Product D and E caused less vasoconstriction than the brand name product. This double blind study showed that all locally made products could improve psoriasis to the same extent as the brand name product, but there was more recurrence of psoriasis while using all the locally made products. It was concluded that locally made products were as effective as the brand name product in the treatment of psoriasis evaluated over a 2 week peroid, but more recurrence was observed with locally made products. |
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Authors:
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Siripen Puavilai; Panwipa Krisadaphong; Vichit Leenutaphong; Pravit Asawanonda; Rutsanee Akaraphan; Tanusin Ploysangham; Suwanna Ruangkarnchanasetr; Nopadon Noppakun; Somyot Charuwichitratana; Kanokvalai Kulthanan; Porntip Huiprasert; Poohglin Tresukosol; Suwirakorn Ophaswongse |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 85 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-09-25 Completed Date: 2002-10-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: 789-99 Citation Subset: IM |
Affiliation:
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Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Anti-Inflammatory Agents / administration & dosage*, therapeutic use* Clobetasol / administration & dosage*, analogs & derivatives*, therapeutic use* Drugs, Generic / administration & dosage*, therapeutic use* Glucocorticoids Humans Psoriasis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Drugs, Generic; 0/Glucocorticoids; 25122-41-2/Clobetasol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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