Document Detail

Comparative study of efficacy and safety of oral versus vaginal misoprostol for induction or labour.
MedLine Citation:
PMID:  24431667     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: To compare the efficacy of oral with vaginal misoprostol for induction of labour.
DESIGN: A randomized trial.
SETTING: Tertiary care hospital.
PARTICIPANTS: Two hundred women requiring induction of labour.
METHODS: Group A received oral misoprostol 50 mcg 6 hourly maximum 4 doses to 100 patients and Group B received vaginal misoprostol 50 mcg 6 hourly maximum 4 doses to 100 patients. When the patient entered active stage of labour i.e. clinically adequate constractions of 3/10 min of >40 s duration, and cervical dilatation of with 4 cm, further doses of misoprostol were not administered. Statistical analysis was done using chi-square test and t test.
RESULT: Both groups were comparable with respect to maternal age, gestational age, indication of induction and initial modified Bishops score Mean number of dosage required for successful induction were significantly less in vaginal group than oral group (in oral groups A were 2.73 + 0.58, and in vaginal Group B 2.26 + 0.52, P value < 0.0001 highly significant). The induction delivery interval was significantly less in vaginal group than oral group (Group A 15.24 + 3.47 h Group B 12.74 + 2.60 h, P < 0.0001 highly significant). Oxytocin augmentation required was less in vaginal group. 26 caesarean sections were performed in oral group and 17 caesarean sections were done in vaginal group (P value 0.06 NS). APGAR score, birth weight, NICU admissions showed no difference between the two groups.
CONCLUSION: This study shows that vaginal route of administration of misoprostol is preferable to oral route for induction of labour when used in equivalent dosage of 50 mcg 6 hourly.
Varsha Laxmikant Deshmukh; Kanan Avinash Yelikar; Vandana Waso
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Publication Detail:
Type:  Journal Article     Date:  2013-05-03
Journal Detail:
Title:  Journal of obstetrics and gynaecology of India     Volume:  63     ISSN:  0971-9202     ISO Abbreviation:  J Obstet Gynaecol India     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2014-01-16     Completed Date:  2014-01-16     Revised Date:  2014-10-01    
Medline Journal Info:
Nlm Unique ID:  0374763     Medline TA:  J Obstet Gynaecol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  321-4     Citation Subset:  -    
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