Document Detail

Comparative study of dilated cardiomyopathy and specific heart muscle diseases from pathophysiological aspects--echocardiographic observation.
MedLine Citation:
PMID:  2148354     Owner:  NLM     Status:  MEDLINE    
To investigate the causative factors of dilated cardiomyopathy (DCM), 29 DCM patients were echocardiographically and histopathologically compared with 17 patients with specific heart muscle diseases mimicking DCM. These consisted of 6 cases of myocarditis and 11 of alcoholic heart muscle disease. Myocarditis patients had less dilation of the left ventricle, more marked segmental wall motion abnormality on admission and more extensive myocardial fibrosis than patients with alcoholic heart muscle disease and DCM. Four myocarditis patients died of congestive heart failure before showing a marked dilatation of the left ventricle. The alcoholic heart muscle disease patients revealed diffuse wall motion abnormality on admission. Out of these 8 patients who had abstained showed amelioration. However, in 3 who had not abstained, both wall motion abnormality and dilatation of the left ventricle markedly progressed and 2 died of congestive heart failure. Although the DCM patients as a group showed deterioration throughout the follow-up period, individual patients revealed a variety of echocardiographic and pathological findings, which led to the regrouping of 29 patients with DCM into 2 subgroups. One group had characteristic features similar to these of patients with myocarditis, and the other had characteristics similar to these of patients with alcoholic heart muscle disease. These findings suggested that different causative factors might coexist in DCM.
O Nakanishi; Y Yokota; H Fukuzaki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  54     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-02-14     Completed Date:  1991-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1147-57     Citation Subset:  IM    
1st Department of Internal Medicine, Kobe University School of Medicine, Japan.
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MeSH Terms
Cardiomegaly / pathology
Cardiomyopathies / pathology,  physiopathology*,  ultrasonography
Cardiomyopathy, Alcoholic / pathology,  physiopathology,  ultrasonography
Cardiomyopathy, Dilated / pathology,  physiopathology*,  ultrasonography
Endomyocardial Fibrosis / pathology
Follow-Up Studies
Middle Aged
Myocardial Contraction
Myocarditis / pathology,  physiopathology,  ultrasonography
Myocardium / pathology

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