Document Detail

Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats.
MedLine Citation:
PMID:  8259378     Owner:  NLM     Status:  MEDLINE    
The effects of oils enriched with gamma-linolenic acid (GLA) on blood pressure and pressor responses were examined in spontaneously hypertensive rats (SHR). Rats were fed purified diets containing evening primrose (EPO), black currant (BCO), borage (BOR) or fungal (FGO) oils for 7 weeks. Significant reductions in blood pressure were obtained in SHR rats maintained on diets enriched with GLA oils. The antihypertensive effect was not associated with enhanced pressor responsiveness to norepinephrine or angiotensin II. Moreover, no differences were found in blood pressure responses to the calcium channel blocker, verapamil. The results suggest that GLA-enriched oils inhibit the development of hypertension in the SHR rat. The blood pressure lowering effect is not mediated by altered pressor responses to vasoconstrictor hormones or intracellular calcium mechanisms.
M M Engler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  49     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  809-14     Citation Subset:  IM    
Department of Physiological Nursing, University of California, San Francisco 94143-0610.
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MeSH Terms
Blood Pressure / drug effects*
Dietary Fats / pharmacology*,  therapeutic use
Fatty Acids / analysis
Fatty Acids, Essential / pharmacology,  therapeutic use
Hypertension / diet therapy,  physiopathology*
Linoleic Acids
Plant Oils / pharmacology*,  therapeutic use
Rats, Inbred SHR / physiology*
Sesame Oil / pharmacology,  therapeutic use
Vasoconstriction / drug effects*
gamma-Linolenic Acid / pharmacology,  therapeutic use
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Mucor javanicus oil; 0/Plant Oils; 0/borage oil; 506-26-3/gamma-Linolenic Acid; 65546-85-2/Efamol; 8008-74-0/Sesame Oil; 97676-19-2/black currant oil

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