| Comparative study of cyclocytidine and arabinosylcytosine disposition in rats. | |
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MedLine Citation:
|
PMID: 2464769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The stability of cyclocytidine (II) in aqueous solutions decreased with increasing pH and temperature. After intravenous injection to rats the biphasic decline of cyclocytidine in the serum was accompanied by simultaneous formation of arabinosylcytosine. Since under physiological conditions (37 degrees C, pH 7.2) the half-lifetime of cyclocytidine dissolved in water was 5 hours, the very early appearance of arabinosylcytosine in the serum of rats suggests that various hydrolytic enzymes may also be responsible for the conversion of cyclocytidine in to arabinosylcytosine in vivo. An equimolar dose of arabinosylcytosine (I) injected to rats produced serum levels which were several times higher than those of cyclocytidine under the same conditions. Since the rate constant of overall elimination was similar for both compounds, this difference in serum levels may most probably be explained by a much higher distribution volume of cyclocytidine resulting also in a higher plasmatic clearance of this compound. |
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Authors:
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L Novotný; H Farghali; I Janků; J Beránek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neoplasma Volume: 35 ISSN: 0028-2685 ISO Abbreviation: Neoplasma Publication Date: 1988 |
Date Detail:
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Created Date: 1989-03-23 Completed Date: 1989-03-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0377266 Medline TA: Neoplasma Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 707-14 Citation Subset: IM |
Affiliation:
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Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ancitabine
/
blood,
pharmacokinetics* Animals Chromatography, High Pressure Liquid Cytarabine / analogs & derivatives*, blood, pharmacokinetics* Half-Life Hydrolysis Male Rats Rats, Inbred Strains Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
|
147-94-4/Cytarabine; 31698-14-3/Ancitabine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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