Document Detail

Comparative study of the clinical effects of tofizopam, nitrazepam and placebo as oral premedication.
MedLine Citation:
PMID:  7002178     Owner:  NLM     Status:  MEDLINE    
In a double-blind randomized study 47 patients received tofizopam 100 mg orally the night before operation, and 100 mg on the morning of operation; 49 patients received nitrazepam 5 mg and 50 patients received placebo. On average the nitrazepam group slept better and were better sedated than the tofizopam or placebo groups. Compared with placebo or nitrazepam, tofizopam decreased the excitement of the patients. The effect tofizopam on apprehension and excitement was significantly better than those of placebo or nitrazepam. Nitrazepam, but not tofizopam, significantly decreased the induction requirements of thiopentone.
A Pakkanen; J Kanto; L Kangas; M Mansikka
Related Documents :
2907978 - Preventive measures for stress ulcers in burn patients.
338398 - A comparison of maprotiline (ludiomil) and amitriptyline (1).
9361168 - Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining...
7272608 - Guided mourning for morbid grief: a controlled study.
3488718 - Morbidity and mortality of coronary artery surgery after the age of 70 years.
23075518 - Effects of age on outcome in the sentis trial: better outcomes in elderly patients.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  52     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1009-12     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Anti-Anxiety Agents*
Benzodiazepines* / administration & dosage,  pharmacology
Clinical Trials as Topic
Double-Blind Method
Hemodynamics / drug effects
Middle Aged
Nitrazepam* / administration & dosage,  pharmacology
Preanesthetic Medication*
Random Allocation
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Placebos; 12794-10-4/Benzodiazepines; 146-22-5/Nitrazepam; 22345-47-7/tofisopam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Correlations between NEFA and ketone bodies in normal and diabetic subjects
Next Document:  Effects of concentration of local anaesthetic drugs in extradural block.