Document Detail

Comparative study of chronotropic and inotropic effects of dopamine and seven derivatives on the isolated, blood-perfused dog atrium.
MedLine Citation:
PMID:  639356     Owner:  NLM     Status:  MEDLINE    
1. The effects of seven dopamine amino acid conjugated derivatives were compared with those of dopamine on sinus rate and contractile force using the isolated, blood-perfused dog atrium preparation. 2. Each of these dopamine derivatives induced dose-related positive chronotropic and inotropic effects. 3. The positive chronotropic and inotropic effects were obtained with the same rank order of potency for each effect with six of the dopamine derivatives. Their rank order and relative potency (dopamine = 1000) were: N-Ileu-dopamine (3) greater than N-Glu-Pro-dopamine (1) = N-Ala-Glu-dopamine (1) greater than N-Gly-Gly-dopamine (0.3) = N-gamma-Glu-dopamine (0.3) greater than N-Gly-Gly-Leu-dopamine (0.1) greater than N-Gly-Gly-Pro-dopamine (0.01). 4. In doses producing equal positive inotropic effects, the positive chronotropic effect of N-Gly-Gly-Leu-dopamine was much less than with the other derivatives tested. Its potency compared to dopamine (= 1000) was 0.3 for the inotropic and 0.1 for the chronotropic effect. 5. The duration of action of doses of the derivatives producing approximately equal positive inotropic responses was in the order N-Ileu-dopamine = N-gamma-Glu-dopamine = N-Gly-Pro-dopamine = N-Ala-Glu-dopamine greater than N-Gly-Gly-dopamine = N-Gly-Gly-Leu-dopamine = N-Gly-Gly-Pro-dopamine greater than dopamine.
S Chiba
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  5     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1978 Jan-Feb
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  IM    
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MeSH Terms
Dopamine / analogs & derivatives*,  pharmacology*
Heart Rate / drug effects*
Myocardial Contraction / drug effects*
Stimulation, Chemical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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