Document Detail


Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits.
MedLine Citation:
PMID:  12540035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compares the chronic toxicity of two anthracyclines--daunorubicin and doxorubicin, commonly used for induction of anthracycline cardiomyopathy in the rabbit model. Such a comparative study has not been published until now. Both drugs were administered intravenously to male Chinchilla rabbits in doses at 3 mg/kg (50 mg/m2) once weekly for 10 weeks. Selected biochemical, haematological and cardiovascular parameters and body weights were regularly monitored; additionally, a histological evaluation of heart, kidney and liver was performed at the end of the experiment. In the daunorubicin group, there were marked signs of the progressive development of heart failure, like the significant increases of the pre-ejection period/left ventricular ejection time index values (up to 134%)--and histological changes within the myocardium were also observed. On the other hand, the 10-week doxorubicin administration did not cause these changes that are typical for heart injury. Haematotoxicity, manifested particularly by aplastic anaemia, was apparent in both the experimental groups. Significant body weight loss (by 45.2%) and high premature mortality (100% versus 36.4%) reflected a greater general toxicity, especially nephrotoxicity of doxorubicin in comparison with daunorubicin. Further studies are necessary to find a possible explanation for these findings.
Authors:
Ivona Klimtová; Tomás Simůnek; Yvona Mazurová; Radomír Hrdina; Vladimír Gersl; Michaela Adamcová
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  21     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-23     Completed Date:  2003-06-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  649-57     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic. klimtova@faf.cuni.cz
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibiotics, Antineoplastic / toxicity*
Body Weight / drug effects
Clinical Chemistry Tests
Daunorubicin / toxicity*
Disease Models, Animal
Doxorubicin / toxicity*
Heart / drug effects
Heart Failure / chemically induced,  pathology
Heart Ventricles / drug effects,  pathology,  physiopathology
Hemodynamics / drug effects
Kidney / drug effects,  pathology
Male
Myocardium / pathology
Rabbits
Toxicity Tests, Chronic
Ventricular Dysfunction, Left / chemically induced,  pathology
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 20830-81-3/Daunorubicin; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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