Document Detail

Comparative study of cervical laminar tents prior to extra-amniotic injection of ethacridine lactate (Rivanol) and a condom-nelathon catheter method for second-trimester pregnancy interruption in Vietnam.
MedLine Citation:
PMID:  10461002     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether the regimen for termination of second-trimester pregnancies using laminaria tents 12-24 h prior to extra-amniotic ethacridine lactate (Rivanol) instillation, is more effective in shortening the insertion-expulsion interval than the presently used method of abortion induction by a condom/Nelathon catheter. DESIGN: A prospective randomised comparative study was performed at Uong Bi General Hospital in Quang Ninh Province, Vietnam, on 91 women undergoing pregnancy termination in the second trimester. INTERVENTIONS: The subjects were randomly allocated to 2 treatment groups, receiving either the Nelathon catheter-condom method (n = 50) or by insertion of a laminaria tent into the cervical canal for preinduction, 13-29 h before extra-amniotic instillation of ethacridine lactate (n = 34). Seven subjects were not pretreated with the laminaria tent. MAIN OUTCOME MEASURES: The insertion-expulsion intervals and the incidence of side effects were assessed. RESULTS: The mean insertion-expulsion interval in the 2 groups was not significantly different (mean 27.5 +/- 16.1 and 26.4 +/- 16.4 h, respectively), calculating the insertion-expulsion interval from the start of active treatment, i.e. from the instillation of Rivanol or insertion of the Nelathon catheter and condom, until expulsion of the fetus. CONCLUSIONS: The laminaria-Rivanol method for pregnancy interruption is not more advantageous than the existing Nelathon catheter-condom method. Simple, successful and cost-effective methods in achieving second-trimester abortion in the Vietnamese context have therefore to be identified and tested.
A Järnbert; B Klang; N T Vinh; N N Ham
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  48     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1999  
Date Detail:
Created Date:  1999-12-03     Completed Date:  1999-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  IM    
Division of International Health Care Research, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Abortifacient Agents / administration & dosage,  pharmacology*
Abortion, Induced / methods*
Cervix Uteri
Ethacridine / administration & dosage,  pharmacology*
Oxytocin / therapeutic use
Pregnancy Trimester, Second
Prospective Studies
Reg. No./Substance:
0/Abortifacient Agents; 442-16-0/Ethacridine; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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