Document Detail


Comparative study of the bronchodilating effects of (-)- and (+)-oxyphenonium bromide.
MedLine Citation:
PMID:  3144299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Racemic oxyphenonium bromide, its enantiomers and placebo were inhaled by eight adult patients with chronic airflow obstruction, in a four-way double-blind cross-over study. 2. Forced expiratory volume in one second (FEV1) and slow inspiratory vital capacity (VC) were measured during the first 6 h after inhalation. 3. (+)-Oxyphenonium was found to be the active enantiomer (eutomer), providing better bronchodilation than (+/-)-oxyphenonium. 4. The distomer, (-)-oxyphenonium, showed only a slight effect on FEV1 and VC as compared with placebo.
Authors:
K G Feitsma; D S Postma; G H Koëter; G D Nossent; B F Brenth; R A de Zeeuw
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  25     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1989-02-06     Completed Date:  1989-02-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  683-7     Citation Subset:  IM    
Affiliation:
Department of Analytical Chemistry and Toxicology, Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bronchodilator Agents*
Clinical Trials as Topic
Double-Blind Method
Female
Forced Expiratory Volume
Humans
Lung Diseases, Obstructive / drug therapy*,  physiopathology
Male
Middle Aged
Oxyphenonium / pharmacology*,  therapeutic use
Quaternary Ammonium Compounds / pharmacology*
Random Allocation
Stereoisomerism
Time Factors
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 0/Quaternary Ammonium Compounds; 14214-84-7/Oxyphenonium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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