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MedLine Citation:
PMID:  22191704     Owner:  NLM     Status:  Publisher    
COMPARATIVE STUDY BETWEEN PORCINE SMALL INTESTINAL SUBMUCOSA AND BUCCAL MUCOSA IN A PARTIAL URETHRA SUBSTITUTION IN RABBITS. Purpose: Several urethral conditions may require tissue substitution. One collagen-base biomaterial that recently emerged as an option is small intestinal submucosa (SIS). The aim of this study was to compare the results of SIS and buccal mucosa for urethral substitution in rabbits. Material and Methods: 36 North Folk male rabbits were randomized into three groups. In all animals a 10x5mm urethral segment was excised and the urethral defect was repaired using a one-layer SIS patch (Group I); four-layer SIS (Group II) or buccal mucosa (Group III). Urethrography was performed preoperatively and after 12 weeks. After sacrifice, graft retraction was objectively measured using Scion Image® computer analysis and by calculation of ellipse area. The grade of fibrosis, inflammatory reaction, vascular/epithelial regeneration and collagen III/I ratio were analyzed by Hematoxylin/eosin and Picrosirius red staining. Results: Urethrography confirmed a wide urethral caliber without any signs of strictures after surgery. Urethral fistulae was diagnosed in 8,3% of cases (1 animal each group). Average graft shrinkage was 55.2% in GI; 44.2% in GII and 57.2% in GIII (p<0.05). The intensity of chronic inflammation, fibrosis, epithelium regeneration and neovascularization was similar in all groups (p>0.05). Collagen III/I ratio was higher in GII (GI:119,6; GII: 257,2 and GIII: 115,0); p<0,01. Conclusions: The four-layer SIS is more advantageous than one-layer SIS and buccal mucosa for urethral substitution in rabbits.
Paulo Roberto Kawano; Oscar Eduardo Hidetoshi Fugita; Hamilto Akihissa Yamamoto; Juliany Gomes Quitzan; Carlos Padovani; João L Amaro
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-22
Journal Detail:
Title:  Journal of endourology / Endourological Society     Volume:  -     ISSN:  1557-900X     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807503     Medline TA:  J Endourol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
São Paulo State University, Department of Urology, Botucatu, Brazil;
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