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Comparative study between doses of intrathecal morphine for analgesia after caesarean.
MedLine Citation:
PMID:  24565347     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND AND OBJECTIVES: Analgesia after caesarean section is important because postpartum women with pain have difficulty in mobility, which undermines breastfeeding. Intrathecal morphine provides adequate and prolonged analgesia after cesarean. The aim of this study was to compare the quality of analgesia provided by two doses of intrathecal morphine and its side effects in patients undergoing cesarean section.
METHOD: The study included 123 pregnant women with gestational age over 38 weeks and scheduled for cesarean section. The women were randomly allocated into two groups to receive either 50 or 100μg of intrathecal morphine (Group 50/Group 100). All patients were intrathecally anesthetized with 12mg of 0.5% hyperbaric bupivacaine. Patients were assessed between the 9(th) and 11(th) hour and the 22(nd) and 24(th) hour after blockade for quality of analgesia, analgesic consumption, side effects, and main cause of discomfort in the first 24hours after surgery.
RESULTS: There was similarity between groups regarding anthropometric data and obstetric history. There was no statistical difference in pain intensity between groups. In both groups, pain was more intense in the first 12hours after anesthesia (p < 0.001). Tramadol hydrochloride consumption and time to first dose were similar in both groups. Pruritus was the most common side effect, with statistically higher incidence in Group 100 (p = 0.026).
CONCLUSIONS: Intrathecal morphine 50μg provides the same quality of analgesia as 100μg, with a lower incidence of side effects.
Francisco Amaral Egydio de Carvalho; Sérgio B Tenório
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Publication Detail:
Type:  Journal Article     Date:  2013-12-05
Journal Detail:
Title:  Brazilian journal of anesthesiology (Elsevier)     Volume:  63     ISSN:  0104-0014     ISO Abbreviation:  Braz J Anesthesiol     Publication Date:    2013 Nov-Dec
Date Detail:
Created Date:  2014-02-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101624623     Medline TA:  Braz J Anesthesiol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  492-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.
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