| Comparative study of the activity of boric, benzene-boronic and methyl-benzene-boronic acids upon respiration, general metabolism and systemic hemodynamics of the anesthetized dog. | |
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MedLine Citation:
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PMID: 1174408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors compared the action of boric, benzene-boronic and p-methyl-benzene-boronic acids on respiration and general metabolism and on systemic hemodynamics of the anesthetized dog. They further investigated the effects on the arterial blood pressure in the rat and on the isolated rabbit heart. In the dogs, the three acids were shown to have no significant action on the systolic, diastolic and mean arterial blood pressures and a slight stimulating action on the differential arterial blood pressure. On the contrary, in the rat, all the acids were hypotensive. This action was dose dependent. In the entire animal, as well as in the isolated rabbit heart, benzene-boronic and p-methyl-benzene-boronic acids depressed the myocardial contractility. Whereas boric acid did not act on the heart contractility in situ in anesthetized dogs, it slightly stimulated the myocardial contractility of the isolated rabbit heart. The two acids seemed to be directly active on the myocardial cell. In the anesthetized dog, cardiac performances were first depressed then stimulated. Both benzene-boronic and p-methyl-benzene-boronic acids were ventilatory depressors: they reduced ventilatory output and rhythm, they first decreased then increased total O2 consumption and CO2 production. |
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Authors:
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Pham-Huu-Chanh; I Sokhan; P Kan |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 25 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-12-11 Completed Date: 1975-12-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 1023-8 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzene Derivatives / pharmacology Blood Pressure / drug effects Boric Acids / pharmacology* Boronic Acids / pharmacology* Cardiac Output / drug effects Dogs Female Hemodynamics / drug effects* Male Myocardial Contraction / drug effects Oxygen Consumption / drug effects Rabbits Rats Respiration / drug effects* Toluene / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Benzene Derivatives; 0/Boric Acids; 0/Boronic Acids; 108-88-3/Toluene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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