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Comparative study of DFDBA in combination with enamel matrix derivative versus DFDBA alone for treatment of periodontal intrabony defects at 12 months post-surgery.
MedLine Citation:
PMID:  20054593     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The aim of this randomized double-blind, clinical trial was to compare the use of enamel matrix derivative (EMD) and demineralised freeze-dried bone allografts (DFDBA) with DFDBA alone for the treatment of human periodontal intrabony defects at 12 months post-surgery. Fifty-six intrabony osseous defects in 56 periodontis patients were randomly assigned to the test group (DFDBA + EMD) or the control group (DFDBA) for periodontal treatment. Clinical and radiographic measurements were made at the baseline and after 12 months. Compared to baseline, the 12-month results indicated that both treatment modalities resulted in significant changes in all clinical parameters (gingival index, bleeding on probing, probing depth (PD), clinical attachment level (CAL), gingival recession; P < 0.05) and radiographic parameters (hard tissue fill (HTF) and bone depth reduction; P < 0.05). Furthermore, statistically significant differences were found in the test group compared to the control group in PD reduction (5.0 mm vs. 4.0 mm; P < 0.05), CAL gain (4.0 mm vs. 3.25 mm), and HTF (4.0 mm vs. 3.5 mm; P < 0.05). In the test group, 25% of sites gained >4 mm of CAL, while in the control group, 7.1% of sites gained >4 mm of CAL. Both treatments showed a good soft and hard periodontal tissue response. At 12 months post-surgery, the combined use of DFDBA and EMD seemed to produce a statistically significant improvement of PD reduction, CAL gain, and HTF.
Authors:
Simone Domenico Aspriello; Luigi Ferrante; Corrado Rubini; Matteo Piemontese
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Publication Detail:
Type:  Journal Article     Date:  2010-01-07
Journal Detail:
Title:  Clinical oral investigations     Volume:  15     ISSN:  1436-3771     ISO Abbreviation:  Clin Oral Investig     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9707115     Medline TA:  Clin Oral Investig     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  D    
Affiliation:
Periodontology-Department of Clinical and Dental Sciences, Polytechnic University of the Marche, Via Tronto 10/a, Torrette di Ancona, Italy.
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