Document Detail


Comparative studies with beta-(Tyr9)melanotropin-(9-18) and amphetamine on open-field behavior and striatal dopamine uptake and release.
MedLine Citation:
PMID:  6473485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of beta-(Tyr9)melanotropin-(9-18) and amphetamine on the open-field behavior and the striatal dopamine uptake and release were compared. beta-(Tyr9)melanotropin-(9-18) at doses of 1 microgram (icv) or 2 micrograms (icv) increased the ambulation of the rats, while in a dose of 5 micrograms (icv), it had no effect. Amphetamine had a similar dose-related effect on ambulation. This peptide also increased the rearing activity, in doses of 2 micrograms or 5 micrograms (icv), while amphetamine was effective only in a dose of 2 micrograms (icv). beta-(Tyr9)melanotropin-(9-18) at doses of 1 microgram, 2 micrograms or 5 micrograms (icv) increased the grooming, while amphetamine at the same doses decrease it. The peptide had no significant influence on the striatal dopamine uptake and release, whereas amphetamine markedly decreased the uptake and facilitated the release in a dose-related manner. These results suggest that although beta-(Tyr9)melanotropin-(9-18) and amphetamine have similar effects on the open-field behavior, the mechanisms of action of the two substances are different.
Authors:
L Vécsei; I Bollók; G Telegdy; A V Schally
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological research communications     Volume:  16     ISSN:  0031-6989     ISO Abbreviation:  Pharmacol Res Commun     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-10-22     Completed Date:  1984-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0236354     Medline TA:  Pharmacol Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amphetamine / pharmacology*
Animals
Behavior, Animal / drug effects*
Corpus Striatum / metabolism*
Dopamine / metabolism*
Dose-Response Relationship, Drug
Grooming / drug effects
Male
Melanocyte-Stimulating Hormones / pharmacology*
Peptide Fragments / pharmacology*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Peptide Fragments; 300-62-9/Amphetamine; 75389-13-8/MSH, beta, (9-18), Tyr(9)-; 9002-79-3/Melanocyte-Stimulating Hormones

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