Document Detail

Comparative studies on isolated rat hepatocytes and AS-30D hepatoma cells with leucocidin from Pseudomonas aeruginosa.
MedLine Citation:
PMID:  187964     Owner:  NLM     Status:  MEDLINE    
Leucocidin, one of the cytotoxic principles of Pseudomonas aeruginosa induces potassium loss and swelling in isolated hepatocytes and in AS-30D ascites hepatoma cells in a dose and time dependent manner. Hepatoma cells are more sensitive than normal hepatocytes. As shown by scanning electron microscopy the volume increase of both types of cells is accompanied by disappearance of microvilli. In contrast to phalloidin poisoning no protrusions were formed when the cells were exposed to leucocidin under isotonic conditions.
M Frimmer; J Homann; E Petzinger; U Rufeger; W Scharmann
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  295     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2010-03-12    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Hepatocellular / ultrastructure*
Cell Membrane / ultrastructure
Cell Membrane Permeability / drug effects
Leukocidins / pharmacology*
Liver / drug effects*,  ultrastructure
Liver Neoplasms
Microscopy, Electron, Scanning
Potassium / metabolism
Pseudomonas aeruginosa
Reg. No./Substance:
0/Leukocidins; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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