| Comparative studies on isolated rat hepatocytes and AS-30D hepatoma cells with leucocidin from Pseudomonas aeruginosa. | |
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MedLine Citation:
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PMID: 187964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leucocidin, one of the cytotoxic principles of Pseudomonas aeruginosa induces potassium loss and swelling in isolated hepatocytes and in AS-30D ascites hepatoma cells in a dose and time dependent manner. Hepatoma cells are more sensitive than normal hepatocytes. As shown by scanning electron microscopy the volume increase of both types of cells is accompanied by disappearance of microvilli. In contrast to phalloidin poisoning no protrusions were formed when the cells were exposed to leucocidin under isotonic conditions. |
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Authors:
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M Frimmer; J Homann; E Petzinger; U Rufeger; W Scharmann |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 295 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1976 Oct |
Date Detail:
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Created Date: 1977-02-16 Completed Date: 1977-02-16 Revised Date: 2010-03-12 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 63-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / ultrastructure* Cell Membrane / ultrastructure Cell Membrane Permeability / drug effects Female Leukocidins / pharmacology* Liver / drug effects*, ultrastructure Liver Neoplasms Male Microscopy, Electron, Scanning Potassium / metabolism Pseudomonas aeruginosa Rats |
| Chemical | |
Reg. No./Substance:
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0/Leukocidins; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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