Document Detail


Comparative studies on the interaction of caffeic acid, chlorogenic acid and ferulic acid with bovine serum albumin.
MedLine Citation:
PMID:  20655275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The substitution of the hydrogen on aromatic and esterification of carboxyl group of the phenol compounds plays an important role in their bio-activities. In this paper, caffeic acid (CaA), chlorogenic acid (ChA) and ferulic acid (FA) were selected to investigate the binding to bovine serum albumin (BSA) using UV absorption spectroscopy, fluorescence spectroscopy and synchronous fluorescence spectroscopy. It was found that the methoxyl group substituting for the 3-hydroxyl group of CaA decreased the affinity for BSA and the esterification of carboxyl group of CaA with quinic acid increased the affinities. The affinities of ChA and FA with BSA were more sensitive to the temperature than that of CaA with BSA. Synchronous fluorescence spectroscopy and time-resolved fluorescence indicated that the Stern-Volmer plots largely deviated from linearity at high concentrations and were caused by complete quenching of the tyrosine fluorescence of BSA.
Authors:
Shuang Li; Kelong Huang; Ming Zhong; Jun Guo; Wei-zheng Wang; Ronghua Zhu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-05
Journal Detail:
Title:  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy     Volume:  77     ISSN:  1873-3557     ISO Abbreviation:  Spectrochim Acta A Mol Biomol Spectrosc     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602533     Medline TA:  Spectrochim Acta A Mol Biomol Spectrosc     Country:  England    
Other Details:
Languages:  eng     Pagination:  680-6     Citation Subset:  IM    
Affiliation:
Central South University, Changsha, Hunan 410083, People's Republic China. lishuang 5058@yahoo.com.cn
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MeSH Terms
Descriptor/Qualifier:
Animals
Caffeic Acids / chemistry,  pharmacology*
Cattle
Chlorogenic Acid / chemistry,  pharmacology*
Coumaric Acids / chemistry,  pharmacology*
Protein Binding
Serum Albumin, Bovine / chemistry,  drug effects*
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Structure-Activity Relationship
Temperature
Tyrosine / chemistry
Chemical
Reg. No./Substance:
0/Caffeic Acids; 0/Coumaric Acids; 0/Serum Albumin, Bovine; 1135-24-6/ferulic acid; 327-97-9/Chlorogenic Acid; 331-39-5/caffeic acid; 55520-40-6/Tyrosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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