| Comparative studies on the initiation of labor. | |
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MedLine Citation:
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PMID: 9622309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Parturition is a multifactorial physiological process that involves multiple interconnected positive feedforward and negative feedback loops. Each of these loops is connected to others in a carefully time-regulated fashion. When parturition occurs normally, both fetal and maternal processes are involved. Recent research in pregnant sheep and nonhuman primates shows clearly that the fetus determines the duration of gestation and the mother determines the time of day at which labor begins. The fetal hypothalamo-pituitary-adrenal axis plays a fundamental role in stimulating increased estrogen production in late gestation. Estrogen then activates maternal circadian rhythms that increase oxytocin secretion. As a result, uterine contraction patterns are switched from contractures to contractions. |
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Authors:
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P W Nathanielsz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 78 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-31 Completed Date: 1998-07-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 127-32 Citation Subset: IM |
Affiliation:
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Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. pwn1@cornell.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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embryology,
physiology Animals Circadian Rhythm Estrogens / physiology Feedback Female Fetus / physiology Gestational Age Humans Hypothalamus / embryology, physiology Labor, Obstetric / physiology* Oxytocin / secretion Pituitary Gland / embryology, physiology Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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HD 21350/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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