Document Detail

Comparative studies on the initiation of labor.
MedLine Citation:
PMID:  9622309     Owner:  NLM     Status:  MEDLINE    
Parturition is a multifactorial physiological process that involves multiple interconnected positive feedforward and negative feedback loops. Each of these loops is connected to others in a carefully time-regulated fashion. When parturition occurs normally, both fetal and maternal processes are involved. Recent research in pregnant sheep and nonhuman primates shows clearly that the fetus determines the duration of gestation and the mother determines the time of day at which labor begins. The fetal hypothalamo-pituitary-adrenal axis plays a fundamental role in stimulating increased estrogen production in late gestation. Estrogen then activates maternal circadian rhythms that increase oxytocin secretion. As a result, uterine contraction patterns are switched from contractures to contractions.
P W Nathanielsz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  78     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-31     Completed Date:  1998-07-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
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MeSH Terms
Adrenal Glands / embryology,  physiology
Circadian Rhythm
Estrogens / physiology
Fetus / physiology
Gestational Age
Hypothalamus / embryology,  physiology
Labor, Obstetric / physiology*
Oxytocin / secretion
Pituitary Gland / embryology,  physiology
Grant Support
Reg. No./Substance:
0/Estrogens; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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