Document Detail

Comparative studies on immunological characteristics of IDDM among Asian populations.
MedLine Citation:
PMID:  6680497     Owner:  NLM     Status:  MEDLINE    
Very little information is available related to possible differences in immunological characteristics of IDDM among Asian populations, though it has been reported that IDDM is associated with Bw54-DR4 and B17-DR3 in Japanese and Chinese, respectively. There is virtually no report related to comparative studies on Bf-DM association among Asian populations, while Bf-DM association is reported to be stronger than HLA-DM association in Caucasians. In the present paper, the results of our studies on anti-thyroid antibodies (ATA) of IDDM in Japanese, Chinese and Filipinos are presented. In Japanese, the incidence of ATA positive was higher in IDDM with a duration of less than one year (35.7%) than that in the patients with a duration of one year or more (12.5%). But, there was no such a duration dependent decrease in the incidences of ATA among Chinese or Filipino IDDM. The frequency of BfSS in Filipinos is lower than in Japanese or Chinese. However, no association was found between Bf phenotypes and IDDM in Asian populations. These results indicate that autoimmunity is transient in Japanese IDDM, but persistent in Chinese and Filipinos, and that it is too early to postulate in general that Bf-IDDM association in general populations is stronger than HLA-IDDM association.
K Okai; K Nanjo; A Kawa; M Miyano; Y Nomura; S Kimura; K Miyamura; E Aiyathurai; B Wong; A Panelo
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  141 Suppl     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1985-02-20     Completed Date:  1985-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
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MeSH Terms
Autoantibodies / immunology
Continental Population Groups
Diabetes Mellitus, Type 1 / genetics,  immunology*
HLA Antigens / immunology
Thyroid Gland / immunology
Reg. No./Substance:
0/Autoantibodies; 0/HLA Antigens

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