Document Detail


Comparative studies of cerebral vasodilators on relaxation activities in isolated basilar, mesenteric and pulmonary arteries of rabbits.
MedLine Citation:
PMID:  7098144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of cerebral vasodilators such as bencyclane, cinnarizine, and papaverine were comparatively studied using helically cut basilar and superior mesenteric arteries and radial muscle preparations of pulmonary arteries with the sympathetic nerve isolated from rabbits. The order of relaxation activities on high K+-induced contractures was cinnarizine>bencyclane>papaverine in basilar strips and cinnarizine>papaverine>bencyclane in mesenteric strips. Relaxation responses of basilar strips to cinnarizine and bencyclane were faster and more marked than those seen in mesenteric strips. Responses to papaverine were equipotent in both preparations. The action of cinnarizine alone was irreversible. In mesenteric strips, the order of the sensitivity of contractile responses to cumulatively applied biogenic amines was serotonin>noradrenaline>histamine. Cinnarizine produced an antihistaminergic action, while bencyclane produced an antiserotonergic action. In pulmonary arteries, 6 x 10(-6) g/ml papaverine inhibited contractile responses to 2, 5, and 25 Hz nerve stimulation in a frequency-independent manner together with inhibition of responses to noradrenaline. Bencyclane at 6 x 10(-6) and 10(-5) g/ml selectively inhibited in a dose-dependent manner contractile responses only to 25 Hz without inhibition of responses to noradrenaline. These results were discussed in comparison with findings of the cerebral vasodilators obtained using other experimental techniques. Spiral strips of basilar arteries from rabbits in combination with peripheral arteries may be used as a simple quantitative, and reproducible screening method in a preclinical stage for drug evaluation of cerebral vasodilators.
Authors:
M Egawa; I Nakajima; Y Misu
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  32     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  273-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Basilar Artery / drug effects*
Bencyclane / pharmacology
Cinnarizine / pharmacology
Electric Stimulation
Epinephrine / pharmacology
Female
Histamine / pharmacology
Male
Mesenteric Arteries / drug effects*
Potassium / pharmacology
Pulmonary Artery / drug effects*
Rabbits
Serotonin / pharmacology
Sympathetic Nervous System / physiology
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 2179-37-5/Bencyclane; 298-57-7/Cinnarizine; 50-67-9/Serotonin; 51-43-4/Epinephrine; 51-45-6/Histamine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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