| Comparative studies of cerebral vasodilators on relaxation activities in isolated basilar, mesenteric and pulmonary arteries of rabbits. | |
| | |
MedLine Citation:
|
PMID: 7098144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Effects of cerebral vasodilators such as bencyclane, cinnarizine, and papaverine were comparatively studied using helically cut basilar and superior mesenteric arteries and radial muscle preparations of pulmonary arteries with the sympathetic nerve isolated from rabbits. The order of relaxation activities on high K+-induced contractures was cinnarizine>bencyclane>papaverine in basilar strips and cinnarizine>papaverine>bencyclane in mesenteric strips. Relaxation responses of basilar strips to cinnarizine and bencyclane were faster and more marked than those seen in mesenteric strips. Responses to papaverine were equipotent in both preparations. The action of cinnarizine alone was irreversible. In mesenteric strips, the order of the sensitivity of contractile responses to cumulatively applied biogenic amines was serotonin>noradrenaline>histamine. Cinnarizine produced an antihistaminergic action, while bencyclane produced an antiserotonergic action. In pulmonary arteries, 6 x 10(-6) g/ml papaverine inhibited contractile responses to 2, 5, and 25 Hz nerve stimulation in a frequency-independent manner together with inhibition of responses to noradrenaline. Bencyclane at 6 x 10(-6) and 10(-5) g/ml selectively inhibited in a dose-dependent manner contractile responses only to 25 Hz without inhibition of responses to noradrenaline. These results were discussed in comparison with findings of the cerebral vasodilators obtained using other experimental techniques. Spiral strips of basilar arteries from rabbits in combination with peripheral arteries may be used as a simple quantitative, and reproducible screening method in a preclinical stage for drug evaluation of cerebral vasodilators. |
| | |
Authors:
|
M Egawa; I Nakajima; Y Misu |
Related Documents
:
|
20639684 - Dilation of epicardial coronary arteries by the g protein-coupled estrogen receptor ago... 21095344 - Effect of amlodipine in human internal mammary artery and clinical implications. 7630044 - Vasodilative effect of adrenomedullin in isolated arteries of the dog. 12091244 - Altered guanylyl-cyclase activity in vitro of pulmonary arteries from fetal lambs with ... 19786264 - Noninvasive assessment of the prevalence and characteristics of coronary atheroscleroti... 23247144 - Genetic loci for coronary calcification and serum lipids relate to aortic and carotid c... |
Publication Detail:
|
Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
|
Title: Japanese journal of pharmacology Volume: 32 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 1982 Apr |
Date Detail:
|
Created Date: 1982-09-24 Completed Date: 1982-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 273-81 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Basilar Artery / drug effects* Bencyclane / pharmacology Cinnarizine / pharmacology Electric Stimulation Epinephrine / pharmacology Female Histamine / pharmacology Male Mesenteric Arteries / drug effects* Potassium / pharmacology Pulmonary Artery / drug effects* Rabbits Serotonin / pharmacology Sympathetic Nervous System / physiology Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 2179-37-5/Bencyclane; 298-57-7/Cinnarizine; 50-67-9/Serotonin; 51-43-4/Epinephrine; 51-45-6/Histamine; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel type of lymphocyte-macrophage association revealed electron microscopically in tuberculous l...
Next Document: A comparison of antihypertensive effects of atenolol and propranolol in the spontaneously hypertensi...