Document Detail

Comparative studies of 177Lu-EDTMP and 177Lu-DOTMP as potential agents for palliative radiotherapy of bone metastasis.
MedLine Citation:
PMID:  18372188     Owner:  NLM     Status:  MEDLINE    
(177)Lu is presently considered as an excellent radionuclide for developing bone pain palliation agents owing to its suitable nuclear decay characteristics [T(1/2)=6.73d, E(beta)((max))=497keV, E(gamma)=113keV (6.4%) and 208keV (11%)] and large-scale production feasibility with adequate specific activity using moderate flux research reactors. Multidentate polyaminophosphonic acids have already been proven as the carrier molecule of choice for radiolanthanides and similar +3 metal ions in designing agents for palliative radiotherapy of bone pain due to skeletal metastases. The present paper describes a comparison between (177)Lu complexes of two potential polyaminophosphonic acid ligands, namely Ethylenediaminetetramethylene phosphonic acid (EDTMP) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid (DOTMP) with respect to their radiochemical and in-vivo biological characteristics. Although both the agents have exhibited promising features, the study reveals that (177)Lu-EDTMP has marginally higher skeletal accumulation in comparison to that of (177)Lu-DOTMP, while the latter has slightly faster blood clearance along with lower retention in liver and kidneys in animal models.
Sudipta Chakraborty; Tapas Das; Haladhar Dev Sarma; Meera Venkatesh; Sharmila Banerjee
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Publication Detail:
Type:  Journal Article     Date:  2008-02-17
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  66     ISSN:  0969-8043     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  England    
Other Details:
Languages:  eng     Pagination:  1196-205     Citation Subset:  IM    
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.
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MeSH Terms
Bone Neoplasms
Drug Stability
Lutetium / pharmacokinetics,  therapeutic use*
Organometallic Compounds / pharmacokinetics,  therapeutic use*
Organophosphorus Compounds / pharmacokinetics,  therapeutic use*
Palliative Care
Radioisotopes / pharmacokinetics,  therapeutic use*
Rats, Wistar
Tissue Distribution
Reg. No./Substance:
0/177Lu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid); 0/Organometallic Compounds; 0/Organophosphorus Compounds; 0/Radioisotopes; 0/lutetium ethylenediaminetetramethylene phosphonic acid; 7439-94-3/Lutetium

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