| Comparative studies of 177Lu-EDTMP and 177Lu-DOTMP as potential agents for palliative radiotherapy of bone metastasis. | |
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MedLine Citation:
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PMID: 18372188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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(177)Lu is presently considered as an excellent radionuclide for developing bone pain palliation agents owing to its suitable nuclear decay characteristics [T(1/2)=6.73d, E(beta)((max))=497keV, E(gamma)=113keV (6.4%) and 208keV (11%)] and large-scale production feasibility with adequate specific activity using moderate flux research reactors. Multidentate polyaminophosphonic acids have already been proven as the carrier molecule of choice for radiolanthanides and similar +3 metal ions in designing agents for palliative radiotherapy of bone pain due to skeletal metastases. The present paper describes a comparison between (177)Lu complexes of two potential polyaminophosphonic acid ligands, namely Ethylenediaminetetramethylene phosphonic acid (EDTMP) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid (DOTMP) with respect to their radiochemical and in-vivo biological characteristics. Although both the agents have exhibited promising features, the study reveals that (177)Lu-EDTMP has marginally higher skeletal accumulation in comparison to that of (177)Lu-DOTMP, while the latter has slightly faster blood clearance along with lower retention in liver and kidneys in animal models. |
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Authors:
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Sudipta Chakraborty; Tapas Das; Haladhar Dev Sarma; Meera Venkatesh; Sharmila Banerjee |
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Publication Detail:
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Type: Journal Article Date: 2008-02-17 |
Journal Detail:
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Title: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Volume: 66 ISSN: 0969-8043 ISO Abbreviation: Appl Radiat Isot Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-10-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306253 Medline TA: Appl Radiat Isot Country: England |
Other Details:
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Languages: eng Pagination: 1196-205 Citation Subset: IM |
Affiliation:
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Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Neoplasms Drug Stability Lutetium / pharmacokinetics, therapeutic use* Organometallic Compounds / pharmacokinetics, therapeutic use* Organophosphorus Compounds / pharmacokinetics, therapeutic use* Pain Palliative Care Rabbits Radioisotopes / pharmacokinetics, therapeutic use* Rats Rats, Wistar Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/177Lu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid); 0/Organometallic Compounds; 0/Organophosphorus Compounds; 0/Radioisotopes; 0/lutetium ethylenediaminetetramethylene phosphonic acid; 7439-94-3/Lutetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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