Document Detail

Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations.
MedLine Citation:
PMID:  19720076     Owner:  NLM     Status:  MEDLINE    
Glycogen is a cellular energy store that is crucial for whole body energy metabolism, metabolic regulation and exercise performance. To understand glycogen structure we have purified glycogen particles from rat liver and human skeletal muscle tissues and compared their biophysical properties with those found in commercial glycogen preparations. Ultrastructural analysis of commercial liver glycogens fails to reveal the classical alpha-rosette structure but small irregularly shaped particles. In contrast, commercial slipper limpet glycogen consists of beta-particles with similar branching and chain lengths to purified rat liver glycogen together with a tendency to form small alpha-particles, and suggest it should be used as a source of glycogen for all future studies requiring a substitute for mammalian liver glycogen.
Je-Hoon Ryu; Jace Drain; Jung Hwan Kim; Sean McGee; Angus Gray-Weale; Lynne Waddington; Glendon J Parker; Mark Hargreaves; Sang-Ho Yoo; David Stapleton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-29
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  45     ISSN:  1879-0003     ISO Abbreviation:  Int. J. Biol. Macromol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-28     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  478-82     Citation Subset:  IM    
Department of Food Science and Technology, Sejong University, 98 Gunja-Dong, Gwangjin-Gu, Seoul 143-747, Republic of Korea.
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MeSH Terms
Energy Metabolism
Glycogen / chemistry*,  isolation & purification
Glycogen Synthase / chemistry
Liver / metabolism*
Macromolecular Substances
Microscopy, Electron / methods
Muscle, Skeletal / metabolism*
Ostreidae / metabolism
Reg. No./Substance:
0/Macromolecular Substances; 9005-79-2/Glycogen; EC Synthase

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