Document Detail


Comparative sensitivity of human and bovine erythrocytes to sonolysis by 1-MHz ultrasound.
MedLine Citation:
PMID:  11120370     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This project tested the hypothesis that human erythrocytes, being larger than bovine erythrocytes, would be the more sensitive to sonolysis induced by inertial cavitation. The rationale behind this hypothesis was an earlier demonstration that, among sized populations of erythrocytes, an inverse relation existed between erythrocyte volume and mechanically-induced shear forces in the surrounding medium; viz, the larger the cell, the less shear force required to rupture the cell's membrane. At low erythrocyte densities (i.e., approximately 5% hematocrit) the hypothesis was supported; at high cell densities (i.e., approximately 35% hematocrit) it was not supported. The data are consistent with an ultrasound (US)-induced symmetric implosion of affected gas nuclei as causing the effect at low cell densities; under such conditions there is ample spacing among cells for US-induced symmetric growth and collapse of gas nuclei and the concomitant production of radially-expanding shock waves (which lyse the cells); at high cell densities there is not sufficient spacing among cells for US-induced symmetric growth and collapse of bubbles and an alternative mechanism, possibly asymmetric bubble collapse, becomes operational.
Authors:
M W Miller; T A Sherman; A A Brayman
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  26     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-22     Completed Date:  2001-02-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1317-26     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA. Morton_Miller@urmc.rochester.edu
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MeSH Terms
Descriptor/Qualifier:
Albumins / diagnostic use
Animals
Cattle
Contrast Media
Erythrocyte Volume
Erythrocytes* / cytology
Hematocrit
Hemolysis*
Humans
Ultrasonics*
Grant Support
ID/Acronym/Agency:
R29CA39230-25/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Albumins; 0/Albunex; 0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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