Document Detail

Comparative role of peptide leukotrienes and histamine in the development of nasal mucosal swelling in nasal allergy.
MedLine Citation:
PMID:  10335708     Owner:  NLM     Status:  MEDLINE    
To evaluate the importance of histamine and peptide leukotrienes (LTs) in the development of nasal mucosal swelling in nasal allergy, H1 receptor antagonist (mequitazine, 6 mg, in 2 divided doses, Rhône-Poulenc Rorer, France) and LT receptor antagonist (ONO-1078, pranlukast, 450 mg, in 2 divided doses, Ono Pharmaceutical Co, Ltd, Osaka) were administered orally for 7 days to 16 subjects with perennial nasal allergy to house dust mites, and the effects of receptor blockers of these chemical mediators on the effective cross-sectional area of the nasal cavity (ECA) at rest, at exercise load, at antigen challenge, and at exercise load following antigen challenge were studied. After the administration of H1 receptor antagonist, ECAs at all measurement points slightly increased, but no statistical significance was observed. On the other hand, LT receptor antagonist inhibited ECAs 10 minutes after exercise load, just after the end of antigen challenge, 10 minutes later, and at exercise load following antigen challenge with statistical significance. These results suggest that LTs are involved markedly, and histamine slightly, in the development of nasal mucosal swelling in nasal allergy.
T Numata; A Konno; T Yamakoshi; T Hanazawa; N Terada; H Nagata
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  108     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-03     Completed Date:  1999-06-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-73     Citation Subset:  AIM; IM    
Department of Otorhinolaryngology, School of Medicine, Chiba University, Chiba City, Japan.
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MeSH Terms
Chromones / pharmacology
Histamine / physiology*
Histamine H1 Antagonists / pharmacology
Leukotriene Antagonists / pharmacology
Leukotrienes / physiology*
Nasal Mucosa / physiopathology*,  secretion
Nasal Provocation Tests
Phenothiazines / pharmacology
Physical Exertion
Rhinitis, Allergic, Perennial / etiology,  physiopathology*
Reg. No./Substance:
0/Allergens; 0/Chromones; 0/Histamine H1 Antagonists; 0/Leukotriene Antagonists; 0/Leukotrienes; 0/Phenothiazines; 0/pranlukast; 29216-28-2/mequitazine; 51-45-6/Histamine

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