Document Detail

Comparative responses of the carotid and vertebral arterial systems of rhesus monkeys to betahistine.
MedLine Citation:
PMID:  97809     Owner:  NLM     Status:  MEDLINE    
A newly developed photoelectric method was used in 5 rhesus monkeys to measure the mean transit time of blood through the carotid and vertebral arteries, together with measurement of the blood flow through the tissues of the fronto-parietal area supplied by the carotid artery and of the cerebellar tonsil supplied by the vertebral artery. Following intravenous administration of betahistine mesylate, a histamine analog, the mean transit times of blood through the 2 arteries were equally shortened by 10%, despite a 20% decrease in the mean arterial blood pressure (P less than 0.05). The cerebral tissue and cerebellar tissue blood flow was increased by betahistine, from 70.4 to 81.4 ml/100g/min and from 73.2 to 84.0 ml/100g/min, respectively. Since histamine has been reported to produce a decrease in cardiac output, the increase in cerebral blood flow confirmed that betahistine is a selective cerebral vasodilating agent. However, by comparing the hemodynamic data for the two cerebral arterial systems, it can be concluded that the responses of the carotid and vertebral arterial systems to the vasodilating action of betahistine were essentially the same in extent.
M Tomita; F Gotoh; T Sato; T Amano; N Tanahashi; K Tanaka; M Yamamoto
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  9     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1978 Jul-Aug
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  382-7     Citation Subset:  IM    
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MeSH Terms
Betahistine / pharmacology*
Blood Flow Velocity
Blood Pressure / drug effects
Blood Volume Determination / methods
Carotid Arteries / drug effects*
Cerebellum / blood supply
Cerebrovascular Circulation / drug effects
Frontal Lobe / blood supply
Hemodynamics / drug effects*
Intracranial Pressure / drug effects
Macaca mulatta
Parietal Lobe / blood supply
Pyridines / pharmacology*
Vertebral Artery / drug effects*
Reg. No./Substance:
0/Pyridines; 5638-76-6/Betahistine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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