Document Detail


Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells.
MedLine Citation:
PMID:  24632382     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Myeloperoxidase is an important haem enzyme released by activated leukocytes that catalyses the reaction of hydrogen peroxide with halide and pseudo-halide ions to form different hypohalous acids. Hypohalous acids are chemical oxidants that have potent antibacterial, antiviral and antifungal properties, and as such, play a key role in the human immune system. However, increasing evidence supports an alternative role for myeloperoxidase-derived oxidants in the development of disease. Excessive production of hypohalous acids, particularly during chronic inflammation, leads to the initiation and accumulation of cellular damage that has been implicated in many human pathologies including atherosclerosis, neurodegenerative disease, lung disease, arthritis, inflammatory cancers and kidney disease. This has sparked a significant interest in developing a greater understanding of the mechanisms involved in myeloperoxidase-derived oxidant induced mammalian cell damage. This article will review recent developments in our understanding of the cellular reactivity of the hypochlorous acid, hypobromous acid and hypothiocyanous acid, the major oxidants produced by myeloperoxidase under physiological conditions.
Authors:
Benjamin S Rayner; Dominic T Love; Clare L Hawkins
Publication Detail:
Type:  REVIEW     Date:  2014-3-12
Journal Detail:
Title:  Free radical biology & medicine     Volume:  -     ISSN:  1873-4596     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
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