Document Detail

Comparative randomized study: administration of natural and synthetic surfactant to premature newborns with respiratory distress syndrome.
MedLine Citation:
PMID:  11896865     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The respiratory distress syndrome (RDS) in premature newborns has been etiologically correlated to immature lungs and specifically with surfactant deficiency. Exogenous administration of surfactant is nowadays considered to be the treatment of choice. In this paper we attempt a comparison of clinical results from the administration of natural Alveofact and synthetic Exosurf surfactants in premature newborns with respiratory distress syndrome. METHODS: The study subjects were 92 premature newborns who had been hospitalized in the Department of Neonatology, of the University of Crete. A total of 42 subjects received synthetic surfactant and 50 subjects received natural surfactant. The surfactant was administered in one to three doses, depending on respiratory support requirements. RESULTS: The time of administration was a little longer for the natural surfactant group. The duration of mechanical ventilatory support, requiring oxygen, the duration of hospitalization and the percentage of increase of arterial alveolar partial pressure oxygen ratio (a/APO2) were slightly higher for the synthetic surfactant group. The mortality rate during the neonatal period (28th day) was higher for the synthetic surfactant group than for the natural surfactant group (38.1 vs 24%). A similar tendency was noticed also as regards to complications, e.g. pneumothorax (11.2 vs 5.2%; relative risk (RR) 0.27) intraventricular hemorrhage (34.6 vs 21.1%; RR 0.61), septicemia (11.5 vs 5.2%; RR 0.46) and bronchopulmonary dysplasia (12.5 vs 2.8%; RR 0.22). CONCLUSION: The use of natural surfactant seems to offer more advantages in comparison with its synthetic counterpart.
Christina Giannakopoulou; Eleftheria Hatzidaki; Eftychia Korakaki; Maria Christodoulaki; Kalliope-Maria Margari; Dimitris Mamoulakis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  44     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-05-08     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
Department of Neonatology of the Universityof Crete, Heraklion, Crete, Greece.
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MeSH Terms
Drug Combinations
Fatty Alcohols / therapeutic use
Infant, Newborn
Infant, Premature
Polyethylene Glycols / therapeutic use
Pulmonary Surfactants / therapeutic use*
Respiration, Artificial
Respiratory Distress Syndrome, Newborn / mortality,  therapy*
Reg. No./Substance:
0/Drug Combinations; 0/Fatty Alcohols; 0/Polyethylene Glycols; 0/Pulmonary Surfactants; 107-73-3/Phosphorylcholine; 99732-49-7/Exosurf

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