Document Detail

Comparative quantitative acid-base analysis in coronary artery bypass, severe sepsis, and diabetic ketoacidosis.
MedLine Citation:
PMID:  16280404     Owner:  NLM     Status:  MEDLINE    
The main objective of this study was to assess the relationship of standard base excess (SBE) to delta strong ion difference effective (DeltaSIDe) in critical illness. Critical illness is characterized by variable plasma nonvolatile weak acid components (DeltaA(-)), and SBE becomes discordant with DeltaSIDe. The author hypothesized that both acid-base models are equivalent when SBE and DeltaSIDe are corrected for DeltaA(-). A retrospective chart review was performed to assess this hypothesis by looking at changes in SBE, DeltaSIDe, and DeltaA(-) in 30 coronary artery bypass graft surgery patients, 30 severe sepsis patients, and 15 diabetic ketoacidosis patients. SBE equals the sum of the DeltaSIDe and DeltaA(-). The SBE quantifies the magnitude of the metabolic acid-base derangement, the DeltaSIDe quantifies the plasma strong cation/anion imbalance, and the DeltaA(-) quantifies the magnitude of the hypoalbuminemic alkalosis. The partitioning of SBE into physicochemical components can facilitate analyses of complex acid-base disorders in critical illness.
Edward M Omron
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  20     ISSN:  0885-0666     ISO Abbreviation:  J Intensive Care Med     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2005-11-10     Completed Date:  2006-02-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-26     Citation Subset:  IM    
Division of Pulmonary Medicine, National Naval Medical Center, Bethesda, MD, USA.
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MeSH Terms
Acid-Base Imbalance / diagnosis*,  etiology,  physiopathology
Coronary Artery Bypass / adverse effects*
Coronary Artery Disease / surgery
Critical Illness
Diabetic Ketoacidosis / complications,  physiopathology*
Middle Aged
Retrospective Studies
Systemic Inflammatory Response Syndrome / complications,  physiopathology*

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